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About
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K63-Ub [cytosol]
Stable Identifier
R-DDI-450143
Type
Set [DefinedSet]
Species
Dictyostelium discoideum
Compartment
cytosol
Synonyms
K63-ubiquitin
Locations in the PathwayBrowser
Expand all
Immune System (Dictyostelium discoideum)
Cytokine Signaling in Immune system (Dictyostelium discoideum)
Signaling by Interleukins (Dictyostelium discoideum)
Interleukin-1 family signaling (Dictyostelium discoideum)
Interleukin-1 signaling (Dictyostelium discoideum)
Pellino ubiquitinates IRAK1 (Dictyostelium discoideum)
hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
UBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
TRAF6 is K63 poly-ubiquitinated (Dictyostelium discoideum)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
UBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Dictyostelium discoideum)
UBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
UBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Interleukin-17 signaling (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Innate Immune System (Dictyostelium discoideum)
Toll-like Receptor Cascades (Dictyostelium discoideum)
Toll Like Receptor 10 (TLR10) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
IRAK2 mediated activation of TAK1 complex (Dictyostelium discoideum)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 2 (TLR2) Cascade (Dictyostelium discoideum)
Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
IRAK2 mediated activation of TAK1 complex (Dictyostelium discoideum)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Toll Like Receptor TLR6:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
IRAK2 mediated activation of TAK1 complex (Dictyostelium discoideum)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 3 (TLR3) Cascade (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 4 (TLR4) Cascade (Dictyostelium discoideum)
MyD88-independent TLR4 cascade (Dictyostelium discoideum)
TRIF(TICAM1)-mediated TLR4 signaling (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Dictyostelium discoideum)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
IRAK2 mediated activation of TAK1 complex (Dictyostelium discoideum)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 5 (TLR5) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
IRAK2 mediated activation of TAK1 complex (Dictyostelium discoideum)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Dictyostelium discoideum)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 9 (TLR9) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Dictyostelium discoideum)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Deubiquitination (Dictyostelium discoideum)
Josephin domain DUBs (Dictyostelium discoideum)
ATXN3 family cleave Ub chains (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
PARK2 autoubiquitinates (Dictyostelium discoideum)
PolyUb [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Metalloprotease DUBs (Dictyostelium discoideum)
PSMD14 cleaves K63-linked ubiquitin (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
STAMBPL1 is a deubiquitinase (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Ub-specific processing proteases (Dictyostelium discoideum)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Dictyostelium discoideum)
PolyUb [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
USP19 deubiquitinates RNF123 (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
USP4 deubiquitinate TRAF2,TRAF6 (Dictyostelium discoideum)
PolyUb [cytosol] (Dictyostelium discoideum)
K63polyUb [cytosol] (Dictyostelium discoideum)
K63-Ub [cytosol] (Dictyostelium discoideum)
Participants
members
Homologues of Ub-63-RPS27A(1-76) [cytosol] (Dictyostelium discoideum)
Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
Homologues of Ub-139-UBB(77-152) [cytosol] (Dictyostelium discoideum)
Homologues of Ub-215-UBB(153-228) [cytosol] (Dictyostelium discoideum)
Homologues of Ub-291-UBC(229-304) [cytosol] (Dictyostelium discoideum)
Homologues of Ub-367-UBC(305-380) [cytosol] (Dictyostelium discoideum)
Homologues of Ub-443-UBC(381-456) [cytosol] (Dictyostelium discoideum)
Homologues of Ub-519-UBC(457-532) [cytosol] (Dictyostelium discoideum)
Homologues of Ub-595-UBC(533-608) [cytosol] (Dictyostelium discoideum)
Homologues of Ub-671-UBC(609-684) [cytosol] (Dictyostelium discoideum)
Participant Of
output
ATXN3 family cleave Ub chains
PSMD14 cleaves K63-linked ubiquitin
STAMBPL1 is a deubiquitinase
repeatedUnit
K63polyUb [cytosol]
Inferred From
K63-Ub [cytosol] (Homo sapiens)
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