Reactome | SPOPL [nucleoplasm]

SPOPL [nucleoplasm]

Stable Identifier

R-DDI-5635036-2

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

nucleoplasm

Synonyms

Q54WU7

Locations in the PathwayBrowser

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Signal Transduction (Dictyostelium discoideum)

- Signaling by Hedgehog (Dictyostelium discoideum)
  - Hedgehog 'on' state (Dictyostelium discoideum)
    - GLI2,3 are degraded by the proteasome (Dictyostelium discoideum)
      - SPOP:CUL3:RBX1 [nucleoplasm] (Dictyostelium discoideum)
        
        SPOP dimer [nucleoplasm] (Dictyostelium discoideum)
        
        SPOP:SPOPL [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of SPOPL [nucleoplasm] (Dictyostelium discoideum)
        
        SPOPL [nucleoplasm] (Dictyostelium discoideum)
      - ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Dictyostelium discoideum)
        
        SPOP:CUL3:RBX1 [nucleoplasm] (Dictyostelium discoideum)
        
        SPOP dimer [nucleoplasm] (Dictyostelium discoideum)
        
        SPOP:SPOPL [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of SPOPL [nucleoplasm] (Dictyostelium discoideum)
        
        SPOPL [nucleoplasm] (Dictyostelium discoideum)
    - SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Dictyostelium discoideum)
      - 2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Dictyostelium discoideum)
        
        SPOP:CUL3:RBX1 [nucleoplasm] (Dictyostelium discoideum)
        
        SPOP dimer [nucleoplasm] (Dictyostelium discoideum)
        
        SPOP:SPOPL [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of SPOPL [nucleoplasm] (Dictyostelium discoideum)
        
        SPOPL [nucleoplasm] (Dictyostelium discoideum)
      - ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Dictyostelium discoideum)
        
        SPOP:CUL3:RBX1 [nucleoplasm] (Dictyostelium discoideum)
        
        SPOP dimer [nucleoplasm] (Dictyostelium discoideum)
        
        SPOP:SPOPL [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of SPOPL [nucleoplasm] (Dictyostelium discoideum)
        
        SPOPL [nucleoplasm] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54WU7

Reference Genes

BioGPS Gene:8622026

dictyBase:DDB_G0279425

ENSEMBL:DDB_G0279425

KEGG:ddi:DDB_G0279425

Monarch:8622026

NCBI Gene:8622026

UCSC:Q54WU7

Reference Transcript

RefSeq:XM_636528.1

Participates

as a member of

Homologues of SPOPL [nucleoplasm] (Dictyostelium discoideum)

Other forms of this molecule

RHOBTB3 [trans-Golgi network membrane]

SPOP [nucleoplasm]

Inferred From

SPOPL [nucleoplasm] (Homo sapiens)

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