Reactome | phospho-H2Av2 [nucleoplasm]

phospho-H2Av2 [nucleoplasm]

Stable Identifier

R-DDI-5683942-2

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

nucleoplasm

Synonyms

p-Y143-H2AFX, Q54HV9

Locations in the PathwayBrowser

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DNA Repair (Dictyostelium discoideum)

- DNA Double-Strand Break Repair (Dictyostelium discoideum)
  - DNA Double Strand Break Response (Dictyostelium discoideum)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Dictyostelium discoideum)
      - ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-Y143-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2Av2 [nucleoplasm] (Dictyostelium discoideum)
      - ATM recognizes H2AFX-Nucleosomes (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-Y143-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2Av2 [nucleoplasm] (Dictyostelium discoideum)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-Y143-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2Av2 [nucleoplasm] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54HV9

Gene Names

H2Av2

Reference Genes

BioGPS Gene:8627003 H2Av2

dictyBase:DDB_G0289193

ENSEMBL:DDB_G0289193

KEGG Gene (Dictyostelium discoideum):DDB_G0289193 H2Av2

Monarch:8627003 H2Av2

NCBI Gene:8627003 H2Av2

Reference Transcript

RefSeq:XM_631238.1 H2Av2

Participates

as a member of

Homologues of p-Y143-H2AFX [nucleoplasm] (Dictyostelium discoideum)

Other forms of this molecule

H2Av2 [nucleoplasm]

phospho-H2Av2 [nucleoplasm]

H2Av2 [nucleoplasm]

Inferred From

p-Y143-H2AFX [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 143 (in Homo sapiens)

Coordinate

143

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_636330.1

PRO

Q54HV9