Reactome | ORC4 [nucleoplasm]

ORC4 [nucleoplasm]

Stable Identifier

R-DDI-68519

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

nucleoplasm

Synonyms

Q86AD6

Locations in the PathwayBrowser

Expand all

Cell Cycle (Dictyostelium discoideum)

- Cell Cycle, Mitotic (Dictyostelium discoideum)
  - Mitotic G1 phase and G1/S transition (Dictyostelium discoideum)
    - G1/S Transition (Dictyostelium discoideum)
      - Activation of the pre-replicative complex (Dictyostelium discoideum)
        
        Cdc45 associates with the pre-replicative complex at the origin (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        CDC6:ORC:origin complex [nucleoplasm] (Dictyostelium discoideum)
        
        ORC:origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        CDC6:ORC:origin complex [nucleoplasm] (Dictyostelium discoideum)
        
        ORC:origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA polymerase alpha:primase binds at the origin (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        CDC6:ORC:origin complex [nucleoplasm] (Dictyostelium discoideum)
        
        ORC:origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA polymerase epsilon binds at the origin (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        CDC6:ORC:origin complex [nucleoplasm] (Dictyostelium discoideum)
        
        ORC:origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)

DNA Replication (Dictyostelium discoideum)

- DNA Replication Pre-Initiation (Dictyostelium discoideum)
  - Activation of the pre-replicative complex (Dictyostelium discoideum)
    - Cdc45 associates with the pre-replicative complex at the origin (Dictyostelium discoideum)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        CDC6:ORC:origin complex [nucleoplasm] (Dictyostelium discoideum)
        
        ORC:origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        CDC6:ORC:origin complex [nucleoplasm] (Dictyostelium discoideum)
        
        ORC:origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
    - DNA polymerase alpha:primase binds at the origin (Dictyostelium discoideum)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        CDC6:ORC:origin complex [nucleoplasm] (Dictyostelium discoideum)
        
        ORC:origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
    - DNA polymerase epsilon binds at the origin (Dictyostelium discoideum)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        CDC6:ORC:origin complex [nucleoplasm] (Dictyostelium discoideum)
        
        ORC:origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
  - Assembly of the pre-replicative complex (Dictyostelium discoideum)
    - Assembly of the ORC complex at the origin of replication (Dictyostelium discoideum)
      - Formation of ORC(1-5) complex (Dictyostelium discoideum)
        
        ORC(1-5):origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(1-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(2-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(2-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
      - Formation of ORC(1-6) complex (Dictyostelium discoideum)
        
        ORC(1-5):origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(1-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(2-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(1-6):origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(1-5):origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(1-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(2-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
      - Formation of ORC(2-5) complex (Dictyostelium discoideum)
        
        ORC(2-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
    - CDC6 association with the ORC:origin complex (Dictyostelium discoideum)
      - CDC6 association with ORC(1-6) at replication origins (Dictyostelium discoideum)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(1-6):origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(1-5):origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(1-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(2-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(1-6):origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(1-5):origin of replication [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(1-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC(2-5) [nucleoplasm] (Dictyostelium discoideum)
        
        ORC4 [nucleoplasm] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q86AD6

Reference Genes

BioGPS Gene:8618071

dictyBase:DDB_G0271562

ENSEMBL:DDB_G0271562

KEGG Gene (Dictyostelium discoideum):DDB_G0271562

Monarch:8618071

NCBI Gene:8618071

Reference Transcript

RefSeq:XM_640524.1

Participates

as a component of

as an input of

Formation of ORC(2-5) complex (Dictyostelium discoideum)

Inferred From

ORC4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_645616.1

PRO

Q86AD6

Cite Us!