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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Overlays
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Web
API
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Details Panel
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Citing us
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rad50 [nucleoplasm]
Stable Identifier
R-DDI-75160
Type
Protein [EntityWithAccessionedSequence]
Species
Dictyostelium discoideum
Compartment
nucleoplasm
Synonyms
RAD50, Q54CS9
Locations in the PathwayBrowser
Expand all
DNA Repair (Dictyostelium discoideum)
DNA Double-Strand Break Repair (Dictyostelium discoideum)
DNA Double Strand Break Response (Dictyostelium discoideum)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Dictyostelium discoideum)
ATM phosphorylates MDC1 (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
ATM phosphorylates TP53BP1 at DNA DSBs (Dictyostelium discoideum)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
ATM phosphorylates WHSC1 (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
MDC1 associates with gamma-H2AFX at nuclear foci (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
PPP5C dephosphorylates TP53BP1 (Dictyostelium discoideum)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
TP53BP1 associates with H4K20Me2 at DNA DSBs (Dictyostelium discoideum)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
WHSC1 binds DNA DSBs (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
Sensing of DNA Double Strand Breaks (Dictyostelium discoideum)
Formation of RAD50:MRE11 complex (Dictyostelium discoideum)
RAD50:MRE11A [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
Homology Directed Repair (Dictyostelium discoideum)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Dictyostelium discoideum)
HDR through Homologous Recombination (HRR) (Dictyostelium discoideum)
Homologous DNA Pairing and Strand Exchange (Dictyostelium discoideum)
Presynaptic phase of homologous DNA pairing and strand exchange (Dictyostelium discoideum)
BCDX2 complex stabilizes RAD51 filament (Dictyostelium discoideum)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Dictyostelium discoideum)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
3' overhanging ssDNA-DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Dictyostelium discoideum)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Dictyostelium discoideum)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Dictyostelium discoideum)
3' overhanging ssDNA-DSBs:p-MRN [nucleoplasm] (Dictyostelium discoideum)
p-MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
HDR through MMEJ (alt-NHEJ) (Dictyostelium discoideum)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
MRN and RBBP8 resect DNA DSBs in MMEJ (Dictyostelium discoideum)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
DNA DSBs:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
MRN recruits LIG3:XRCC1 to MMEJ sites (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Dictyostelium discoideum)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Dictyostelium discoideum)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Dictyostelium discoideum)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Dictyostelium discoideum)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Dictyostelium discoideum)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Dictyostelium discoideum)
MRN [nucleoplasm] (Dictyostelium discoideum)
rad50 [nucleoplasm] (Dictyostelium discoideum)
External Reference Information
External Reference
UniProt:Q54CS9
Gene Names
rad50
Reference Genes
BioGPS Gene:8628852 rad50
dictyBase:DDB_G0292786
ENSEMBL:DDB_G0292786
KEGG Gene (Dictyostelium discoideum):DDB_G0292786 rad50
Monarch:8628852 rad50
NCBI Gene:8628852 rad50
Reference Transcript
RefSeq:XM_629460.1 rad50
Participant Of
input
Formation of RAD50:MRE11 complex
hasComponent
MRN [nucleoplasm]
p-MRN [nucleoplasm]
RAD50:MRE11A [nucleoplasm]
Inferred From
RAD50 [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
XP_629462.1
PRO
Q54CS9
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