Reactome | phospho-apm2 [cytosol]

phospho-apm2 [cytosol]

Stable Identifier

R-DDI-8856805

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

p-T156 AP2M1, P54672

Locations in the PathwayBrowser

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Vesicle-mediated transport (Dictyostelium discoideum)

- Membrane Trafficking (Dictyostelium discoideum)
  - Clathrin-mediated endocytosis (Dictyostelium discoideum)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Dictyostelium discoideum)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Dictyostelium discoideum)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - BAR domain proteins recruit dynamin (Dictyostelium discoideum)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Dictyostelium discoideum)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - Clathrin recruits PIK3C2A (Dictyostelium discoideum)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Dictyostelium discoideum)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Dictyostelium discoideum)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Dictyostelium discoideum)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Dictyostelium discoideum)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Dictyostelium discoideum)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Dictyostelium discoideum)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - RAB5 and GAPVD1 bind AP-2 (Dictyostelium discoideum)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Dictyostelium discoideum)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Dictyostelium discoideum)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
        
        p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)
        
        phospho-apm2 [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:P54672

Gene Names

apm2

Reference Genes

BioGPS Gene:8620939 apm2

dictyBase:DDB_G0277139

ENSEMBL:DDB_G0277139

KEGG Gene (Dictyostelium discoideum):DDB_G0277139 apm2

Monarch:8620939 apm2

NCBI Gene:8620939 apm2

Reference Transcript

RefSeq:XM_637657.1 apm2

Participates

as a component of

p-T156 AP-2 Complex [cytosol] (Dictyostelium discoideum)

Other forms of this molecule

apm2 [cytosol]

apm2 [lysosomal membrane]

apm2 [endolysosome membrane]

apm2 [plasma membrane]

apm2 [cytosol]

Inferred From

p-T156 AP2M1 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 156 (in Homo sapiens)

Coordinate

156

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_642749.1

PRO

P54672

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