Reactome | tifA [cytosol]

tifA [cytosol]

Stable Identifier

R-DDI-927868

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

EIF4A3, Q55D61

Locations in the PathwayBrowser

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Metabolism of RNA (Dictyostelium discoideum)

- Deadenylation-dependent mRNA decay (Dictyostelium discoideum)
  - Deadenylation of mRNA (Dictyostelium discoideum)
    - PAN2-PAN3 complex partially deadenylates mRNA (Dictyostelium discoideum)
      - Partially Deadenylated mRNA Complex [cytosol] (Dictyostelium discoideum)
        
        eIF4A [cytosol] (Dictyostelium discoideum)
        
        tifA [cytosol] (Dictyostelium discoideum)
      - Translatable mRNA Complex [cytosol] (Dictyostelium discoideum)
        
        eIF4A [cytosol] (Dictyostelium discoideum)
        
        tifA [cytosol] (Dictyostelium discoideum)
    - ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Dictyostelium discoideum)
      - Partially Deadenylated mRNA Complex [cytosol] (Dictyostelium discoideum)
        
        eIF4A [cytosol] (Dictyostelium discoideum)
        
        tifA [cytosol] (Dictyostelium discoideum)
      - Uridylated partially Deadenylated mRNA Complex [cytosol] (Dictyostelium discoideum)
        
        eIF4A [cytosol] (Dictyostelium discoideum)
        
        tifA [cytosol] (Dictyostelium discoideum)
- Nonsense-Mediated Decay (NMD) (Dictyostelium discoideum)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Dictyostelium discoideum)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Dictyostelium discoideum)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Dictyostelium discoideum)
        
        tifA [cytosol] (Dictyostelium discoideum)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Dictyostelium discoideum)
        
        tifA [cytosol] (Dictyostelium discoideum)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Dictyostelium discoideum)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Dictyostelium discoideum)
        
        tifA [cytosol] (Dictyostelium discoideum)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Dictyostelium discoideum)
        
        tifA [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q55D61

Gene Names

tifA

Reference Genes

dictyBase:DDB_G0269192

ENSEMBL:DDB_G0269192

KEGG Gene (Dictyostelium discoideum):DDB_G0269192 tifA

Participant Of

hasComponent

Core Exon Junction Complex (Core EJC) [cytosol]

hasMember

eIF4A [cytosol]

Other forms of this molecule

tifA [nucleoplasm]

Inferred From

EIF4A3 [cytosol] (Homo sapiens)

Cross References

IntEnz

3.6.4.13

PRO

Q55D61

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