Reactome | ubqD [cytosol]

ubqD [cytosol]

Stable Identifier

R-DDI-939224

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

Ub-63-UBB(1-76), P0CG77

Locations in the PathwayBrowser

Expand all

Immune System (Dictyostelium discoideum)

- Cytokine Signaling in Immune system (Dictyostelium discoideum)
  - Signaling by Interleukins (Dictyostelium discoideum)
    - Interleukin-1 family signaling (Dictyostelium discoideum)
      - Interleukin-1 signaling (Dictyostelium discoideum)
        
        Pellino ubiquitinates IRAK1 (Dictyostelium discoideum)
        
        hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
        
        UBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)
        
        TRAF6 is K63 poly-ubiquitinated (Dictyostelium discoideum)
        
        hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
        
        UBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)
        
        hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Dictyostelium discoideum)
        
        UBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)
        
        hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
        
        UBE2N:UBE2V1:K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)
- Innate Immune System (Dictyostelium discoideum)
  - Toll-like Receptor Cascades (Dictyostelium discoideum)
    - Toll Like Receptor 10 (TLR10) Cascade (Dictyostelium discoideum)
      - MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        IRAK2 mediated activation of TAK1 complex (Dictyostelium discoideum)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 2 (TLR2) Cascade (Dictyostelium discoideum)
      - Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        IRAK2 mediated activation of TAK1 complex (Dictyostelium discoideum)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)
      - Toll Like Receptor TLR6:TLR2 Cascade (Dictyostelium discoideum)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        IRAK2 mediated activation of TAK1 complex (Dictyostelium discoideum)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 4 (TLR4) Cascade (Dictyostelium discoideum)
      - MyD88-independent TLR4 cascade (Dictyostelium discoideum)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Dictyostelium discoideum)
        
        TRAF6-mediated induction of TAK1 complex within TLR4 complex (Dictyostelium discoideum)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        IRAK2 mediated activation of TAK1 complex (Dictyostelium discoideum)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 5 (TLR5) Cascade (Dictyostelium discoideum)
      - MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        IRAK2 mediated activation of TAK1 complex (Dictyostelium discoideum)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Dictyostelium discoideum)
      - MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Dictyostelium discoideum)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 9 (TLR9) Cascade (Dictyostelium discoideum)
      - MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Dictyostelium discoideum)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Dictyostelium discoideum)
        
        K63polyUb [cytosol] (Dictyostelium discoideum)
        
        K63-Ub [cytosol] (Dictyostelium discoideum)
        
        Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)
        
        ubqD [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:P0CG77

Gene Names

ubqD

Reference Genes

BioGPS Gene:8625864 ubqD

dictyBase:DDB_G0286907

ENSEMBL:DDB_G0286907

KEGG Gene (Dictyostelium discoideum):DDB_G0286907 ubqD

Monarch:8625864 ubqD

NCBI Gene:8625864 ubqD

Reference Transcript

RefSeq:XM_632373.1 ubqD

Participant Of

hasMember

Homologues of Ub-63-UBB(1-76) [cytosol]

Other forms of this molecule

ubqD [endocytic vesicle membrane]

ubqD [cytosol]

phospho-ubqD [nucleoplasm]

ubqD [cytosol]

phospho-ubqD [cytosol]

ubqD [endosome membrane]

ubqD [cytosol]

ubqD [nucleoplasm]

ubqD [cytosol]

Inferred From

Ub-63-UBC(1-76) [cytosol] (Homo sapiens)

Ub-63-UBB(1-76) [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine at 63 (in Homo sapiens)

Coordinate

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_637465.1

PRO

P0CG77

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