Reactome | PSMC4:PSMC5 [nucleoplasm]

PSMC4:PSMC5 [nucleoplasm]

Stable Identifier

R-DDI-9918349

Type

Complex

Species

Dictyostelium discoideum

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Cell Cycle (Dictyostelium discoideum)

- Cell Cycle Checkpoints (Dictyostelium discoideum)
  - G1/S DNA Damage Checkpoints (Dictyostelium discoideum)
    - p53-Independent G1/S DNA Damage Checkpoint (Dictyostelium discoideum)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Dictyostelium discoideum)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Dictyostelium discoideum)
        
        26S proteasome [nucleoplasm] (Dictyostelium discoideum)
        
        19S regulatory particle [nucleoplasm] (Dictyostelium discoideum)
        
        19S RP base [nucleoplasm] (Dictyostelium discoideum)
        
        PSMC4:PSMC5 [nucleoplasm] (Dictyostelium discoideum)
- Cell Cycle, Mitotic (Dictyostelium discoideum)
  - Mitotic G1 phase and G1/S transition (Dictyostelium discoideum)
    - G1/S Transition (Dictyostelium discoideum)
      - Cyclin E associated events during G1/S transition (Dictyostelium discoideum)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Dictyostelium discoideum)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Dictyostelium discoideum)
        
        26S proteasome [nucleoplasm] (Dictyostelium discoideum)
        
        19S regulatory particle [nucleoplasm] (Dictyostelium discoideum)
        
        19S RP base [nucleoplasm] (Dictyostelium discoideum)
        
        PSMC4:PSMC5 [nucleoplasm] (Dictyostelium discoideum)
  - Regulation of mitotic cell cycle (Dictyostelium discoideum)
    - APC/C-mediated degradation of cell cycle proteins (Dictyostelium discoideum)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Dictyostelium discoideum)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Dictyostelium discoideum)
        
        26S proteasome [nucleoplasm] (Dictyostelium discoideum)
        
        19S regulatory particle [nucleoplasm] (Dictyostelium discoideum)
        
        19S RP base [nucleoplasm] (Dictyostelium discoideum)
        
        PSMC4:PSMC5 [nucleoplasm] (Dictyostelium discoideum)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Dictyostelium discoideum)
        
        Degradation of multiubiquitinated Cdh1 (Dictyostelium discoideum)
        
        26S proteasome [nucleoplasm] (Dictyostelium discoideum)
        
        19S regulatory particle [nucleoplasm] (Dictyostelium discoideum)
        
        19S RP base [nucleoplasm] (Dictyostelium discoideum)
        
        PSMC4:PSMC5 [nucleoplasm] (Dictyostelium discoideum)
  - S Phase (Dictyostelium discoideum)
    - Cyclin A:Cdk2-associated events at S phase entry (Dictyostelium discoideum)
      - SCF(Skp2)-mediated degradation of p27/p21 (Dictyostelium discoideum)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Dictyostelium discoideum)
        
        26S proteasome [nucleoplasm] (Dictyostelium discoideum)
        
        19S regulatory particle [nucleoplasm] (Dictyostelium discoideum)
        
        19S RP base [nucleoplasm] (Dictyostelium discoideum)
        
        PSMC4:PSMC5 [nucleoplasm] (Dictyostelium discoideum)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

19S RP base [nucleoplasm] (Dictyostelium discoideum)

Inferred From

PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)