Reactome | adrm1-1; adrm1-2 [nucleoplasm]

adrm1-1; adrm1-2 [nucleoplasm]

Stable Identifier

R-DDI-9918361

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

nucleoplasm

Synonyms

ADRM1, Q556N5

Locations in the PathwayBrowser

Expand all

Cell Cycle (Dictyostelium discoideum)

- Cell Cycle Checkpoints (Dictyostelium discoideum)
  - G1/S DNA Damage Checkpoints (Dictyostelium discoideum)
    - p53-Independent G1/S DNA Damage Checkpoint (Dictyostelium discoideum)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Dictyostelium discoideum)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Dictyostelium discoideum)
        
        26S proteasome [nucleoplasm] (Dictyostelium discoideum)
        
        19S regulatory particle [nucleoplasm] (Dictyostelium discoideum)
        
        19S RP base [nucleoplasm] (Dictyostelium discoideum)
        
        adrm1-1; adrm1-2 [nucleoplasm] (Dictyostelium discoideum)
- Cell Cycle, Mitotic (Dictyostelium discoideum)
  - Mitotic G1 phase and G1/S transition (Dictyostelium discoideum)
    - G1/S Transition (Dictyostelium discoideum)
      - Cyclin E associated events during G1/S transition (Dictyostelium discoideum)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Dictyostelium discoideum)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Dictyostelium discoideum)
        
        26S proteasome [nucleoplasm] (Dictyostelium discoideum)
        
        19S regulatory particle [nucleoplasm] (Dictyostelium discoideum)
        
        19S RP base [nucleoplasm] (Dictyostelium discoideum)
        
        adrm1-1; adrm1-2 [nucleoplasm] (Dictyostelium discoideum)
  - Regulation of mitotic cell cycle (Dictyostelium discoideum)
    - APC/C-mediated degradation of cell cycle proteins (Dictyostelium discoideum)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Dictyostelium discoideum)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Dictyostelium discoideum)
        
        26S proteasome [nucleoplasm] (Dictyostelium discoideum)
        
        19S regulatory particle [nucleoplasm] (Dictyostelium discoideum)
        
        19S RP base [nucleoplasm] (Dictyostelium discoideum)
        
        adrm1-1; adrm1-2 [nucleoplasm] (Dictyostelium discoideum)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Dictyostelium discoideum)
        
        Degradation of multiubiquitinated Cdh1 (Dictyostelium discoideum)
        
        26S proteasome [nucleoplasm] (Dictyostelium discoideum)
        
        19S regulatory particle [nucleoplasm] (Dictyostelium discoideum)
        
        19S RP base [nucleoplasm] (Dictyostelium discoideum)
        
        adrm1-1; adrm1-2 [nucleoplasm] (Dictyostelium discoideum)
  - S Phase (Dictyostelium discoideum)
    - Cyclin A:Cdk2-associated events at S phase entry (Dictyostelium discoideum)
      - SCF(Skp2)-mediated degradation of p27/p21 (Dictyostelium discoideum)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Dictyostelium discoideum)
        
        26S proteasome [nucleoplasm] (Dictyostelium discoideum)
        
        19S regulatory particle [nucleoplasm] (Dictyostelium discoideum)
        
        19S RP base [nucleoplasm] (Dictyostelium discoideum)
        
        adrm1-1; adrm1-2 [nucleoplasm] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q556N5

Gene Names

adrm1-1; adrm1-2

Reference Genes

BioGPS Gene:8618685 adrm1-1; adrm1-2

BioGPS Gene:8619291 adrm1-1; adrm1-2

dictyBase:DDB_G0272624

ENSEMBL:DDB_G0272624

KEGG:ddi:DDB_G0272624 adrm1-1; adrm1-2

KEGG:ddi:DDB_G0274093 adrm1-1; adrm1-2

Monarch:8618685 adrm1-1; adrm1-2

Monarch:8619291 adrm1-1; adrm1-2

NCBI Gene:8618685 adrm1-1; adrm1-2

NCBI Gene:8619291 adrm1-1; adrm1-2

UCSC:Q556N5 adrm1-1; adrm1-2

Reference Transcript

Participates

as a component of

19S RP base [nucleoplasm] (Dictyostelium discoideum)

Other forms of this molecule

adrm1-1; adrm1-2 [cytosol]

Inferred From

ADRM1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_645008.1, XP_644405.1

PRO

Q556N5

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q54QQ1	10	phg2 [cytosol] (R-DDI-9687819-12) phg2 [cytosol] (R-DDI-9686937-12) phg2 [cytosol] (R-DDI-9686917-12) phospho-phg2 [cytosol] (R-DDI-5218873-12) phg2 [cytosol] (R-DDI-450328-12) phospho-phg2 [cytosol] (R-DDI-5672654-12) phg2 [cytosol] (R-DDI-5672587-12) phospho-phg2 [cytosol] (R-DDI-5672652-12) phospho-phg2 [plasma membrane] (R-DDI-5672659-12) phospho-phg2 [cytosol] (R-DDI-5672656-12)	0.527	3