PIP3 dephosphorylated to PIP2 by DPTEN

Stable Identifier
R-DME-110459
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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DPTEN (a phosphoinositide phosphatase) catalyses the reversal of PIP3 to PIP2. This mechanism, together with Dp110 activity, regulates the levels of PIP3 which is the second messenger for controlling organism size.

Literature References
PubMed ID Title Journal Year
12163412 The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels.

Oldham, S, Stocker, H, Laffargue, M, Wittwer, F, Wymann, M, Hafen, E

Development 2002
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of DPTEN [cytosol]
Physical Entity
Activity
Authored
Created