Increased PIP3 levels recruit DAkt1 to the membrane

Stable Identifier
R-DME-110463
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
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DAkt (a protein kinase B) is recruited to the plasma membrane due to the interaction between its PH (pleckstrin homology) domain and PIP3. In Drosophila, DAkt appears to be the only target activated by increased PIP3 levels.

Literature References
PubMed ID Title Journal Year
11872800 Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

Stocker, H, Andjelkovic, M, Oldham, S, Laffargue, M, Wymann, MP, Hemmings, BA, Hafen, E

Science 2002
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