Activation of DAkt1 by DPDK1

Stable Identifier
R-DME-110468
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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DPDK1 (a phosphoinositide-dependant protein kinase) controls cellular and organism growth through two effector pathways by activating DAkt and DS6K (S6 kinase). Phosphorylation of the residues Thr308 and Ser473 by DPDK1 (and another downstream kinase?) relieves intermolecular inhibition, allowing the activated DAkt to dissociate from PIP3 and modify its target, DFOXO.

Literature References
PubMed ID Title Journal Year
11752451 PDK1 regulates growth through Akt and S6K in Drosophila.

Rintelen, F, Stocker, H, Thomas, G, Hafen, E

Proc Natl Acad Sci U S A 2001
9368760 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Alessi, DR, Deak, M, Casamayor, A, Caudwell, FB, Morrice, N, Norman, DG, Gaffney, P, Reese, CB, MacDougall, CN, Harbison, D, Ashworth, A, Bownes, M

Curr Biol 1998
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Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
3-phosphoinositide-dependent protein kinase activity of PK61C [cytosol]
Physical Entity
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Authored
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