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TOR signaling pathway
Stable Identifier
R-DME-110523
Type
Pathway
Species
Drosophila melanogaster
ReviewStatus
5/5
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Drosophila signaling pathways (Drosophila melanogaster)
Insulin receptor mediated signaling (Drosophila melanogaster)
TOR signaling pathway (Drosophila melanogaster)
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The target of rapamycin (TOR) proteins are large protein kinases, evolutionarily conserved from yeast to humans. Under optimal nutritional conditions, TOR propagates the insulin-like signal to downstream effectors of cell growth such as D4EBP and DS6K. When nutrients are deficient, TOR transmits no signal and insulin signaling is inhibited.
Participants
Events
DTSC1 AND DTSC2 form a complex
(Drosophila melanogaster)
Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex
(Drosophila melanogaster)
DRheb is inhibited by the TSC1/2 complex
(Drosophila melanogaster)
GEF binds to the inactive DRheb
(Drosophila melanogaster)
GDP is exchanged for GTP on DRheb
(Drosophila melanogaster)
GEF dissociates from DRheb-GTP
(Drosophila melanogaster)
DTOR is positively regulated by DRheb-GTP
(Drosophila melanogaster)
Activated DTOR phosphorylates DS6K
(Drosophila melanogaster)
DPDK1 phosphorylates and activates DS6K
(Drosophila melanogaster)
Activated DTOR also phosphorylates D4EBP
(Drosophila melanogaster)
Participates
as an event of
Insulin receptor mediated signaling (Drosophila melanogaster)
Authored
Jassal, B (2005-06-16)
Created
Jassal, B (2004-02-11)
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