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About
What is Reactome ?
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Ub [cytosol]
Stable Identifier
R-DME-113595
Type
Set [DefinedSet]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
ubiquitin
Locations in the PathwayBrowser
Expand all
Autophagy (Drosophila melanogaster)
Macroautophagy (Drosophila melanogaster)
Selective autophagy (Drosophila melanogaster)
Aggrephagy (Drosophila melanogaster)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Drosophila melanogaster)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Parkin binds Ub:UBE2N:UBE2V1 (Drosophila melanogaster)
Ub:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Parkin transfers Ub to misfolded proteins (Drosophila melanogaster)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
Ub-Misfolded Proteins [cytosol] (Drosophila melanogaster)
Ub-misfolded nascent CFTR [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Drosophila melanogaster)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Drosophila melanogaster)
PolyUb-Misfolded Proteins [cytosol] (Drosophila melanogaster)
Ub-misfolded nascent CFTR [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Drosophila melanogaster)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Drosophila melanogaster)
PolyUb-Misfolded Proteins [cytosol] (Drosophila melanogaster)
Ub-misfolded nascent CFTR [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Drosophila melanogaster)
PolyUb-Misfolded Proteins [cytosol] (Drosophila melanogaster)
Ub-misfolded nascent CFTR [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
PolyUb-Misfolded Proteins [cytosol] (Drosophila melanogaster)
Ub-misfolded nascent CFTR [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Drosophila melanogaster)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
PolyUb-Misfolded Proteins [cytosol] (Drosophila melanogaster)
Ub-misfolded nascent CFTR [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
Ub-Misfolded Proteins [cytosol] (Drosophila melanogaster)
Ub-misfolded nascent CFTR [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Mitophagy (Drosophila melanogaster)
Pink/Parkin Mediated Mitophagy (Drosophila melanogaster)
Parkin promotes the ubiquitination of mitochondrial substrates (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Cell Cycle (Drosophila melanogaster)
Cell Cycle Checkpoints (Drosophila melanogaster)
G1/S DNA Damage Checkpoints (Drosophila melanogaster)
p53-Independent G1/S DNA damage checkpoint (Drosophila melanogaster)
p53-Independent DNA Damage Response (Drosophila melanogaster)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-p-S123-CDC25A [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Metaphase and Anaphase (Drosophila melanogaster)
Mitotic Anaphase (Drosophila melanogaster)
Separation of Sister Chromatids (Drosophila melanogaster)
Degradation of multiubiquitinated Securin (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Drosophila melanogaster)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Proteasome-mediated degradation of PolyUb-FBXL7 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
SCF-FBXL18 ubiquitinates FBXL7 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
SCF-FBXL7 ubiquitinates AURKA (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
multiubiquitinated Skp2:phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of Cyclin B (Drosophila melanogaster)
Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of Securin (Drosophila melanogaster)
Degradation of multiubiquitinated Securin (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Drosophila melanogaster)
APC-Cdc20 mediated degradation of Nek2A (Drosophila melanogaster)
Degradation of multiubiquitinated Nek2A (Drosophila melanogaster)
Multiubiquitinated Nek2A [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Multiubiquitination of Nek2A (Drosophila melanogaster)
Multiubiquitinated Nek2A [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Drosophila melanogaster)
Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
CDK-mediated phosphorylation and removal of Cdc6 (Drosophila melanogaster)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ubiquitinated Cdc6 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ubiquitinated Cdc6 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitin-dependent degradation of Cyclin D (Drosophila melanogaster)
Proteasome mediated degradation of Cyclin D1 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Cellular responses to external stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
UBE2D1,2,3:Ubiquitin [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
DNA Replication (Drosophila melanogaster)
DNA Replication Pre-Initiation (Drosophila melanogaster)
Assembly of the pre-replicative complex (Drosophila melanogaster)
CDT1 association with the CDC6:ORC:origin complex (Drosophila melanogaster)
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
geminin:ubiquitin complex [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitinated geminin is degraded by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
geminin:ubiquitin complex [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
CDK-mediated phosphorylation and removal of Cdc6 (Drosophila melanogaster)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ubiquitinated Cdc6 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ubiquitinated Cdc6 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Developmental Biology (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
Signaling by ROBO receptors (Drosophila melanogaster)
Regulation of expression of SLITs and ROBOs (Drosophila melanogaster)
USP33 deubiquitinates ROBO1 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
USP9X (FAM) binds to ubiquitinated SMAD4 (Drosophila melanogaster)
Ub-SMAD4 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-SMAD4:USP9X [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-SMAD4:USP9X [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Drosophila melanogaster)
Ub-SMAD4 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Transcriptional regulation by RUNX1 (Drosophila melanogaster)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Drosophila melanogaster)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ITCH polyubiquitinates TP73 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Transcriptional regulation by RUNX2 (Drosophila melanogaster)
Regulation of RUNX2 expression and activity (Drosophila melanogaster)
STUB1 polyubiquitinates RUNX2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Transcriptional regulation by RUNX3 (Drosophila melanogaster)
Regulation of RUNX3 expression and activity (Drosophila melanogaster)
Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
E1 mediated ubiquitin activation (Drosophila melanogaster)
E1 bound ubiquitin [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
Ubiquitin:E2 conjugating enzymes [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitin:E2 conjugating enzymes [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
Ub:substrate [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitin:E2 conjugating enzymes [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Proteasomal cleavage of substrate (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
Ubiquitin:E2 conjugating enzymes [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
Ub:substrate [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Transfer of ubiquitin from E1 to E2 (Drosophila melanogaster)
E1 bound ubiquitin [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitin:E2 conjugating enzymes [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
TNFR2 non-canonical NF-kB pathway (Drosophila melanogaster)
NIK-->noncanonical NF-kB signaling (Drosophila melanogaster)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
Dectin-1 mediated noncanonical NF-kB signaling (Drosophila melanogaster)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
IRAK2 mediated activation of TAK1 complex (Drosophila melanogaster)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
IRAK2 mediated activation of TAK1 complex (Drosophila melanogaster)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
IRAK2 mediated activation of TAK1 complex (Drosophila melanogaster)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF(TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Drosophila melanogaster)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
IRAK2 mediated activation of TAK1 complex (Drosophila melanogaster)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
IRAK2 mediated activation of TAK1 complex (Drosophila melanogaster)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Drosophila melanogaster)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Drosophila melanogaster)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Metabolism of RNA (Drosophila melanogaster)
Regulation of mRNA stability by proteins that bind AU-rich elements (Drosophila melanogaster)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Drosophila melanogaster)
AUF1 (hnRNP D0) is ubiquitinylated (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Asparagine N-linked glycosylation (Drosophila melanogaster)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Drosophila melanogaster)
Calnexin/calreticulin cycle (Drosophila melanogaster)
ER Quality Control Compartment (ERQC) (Drosophila melanogaster)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Drosophila melanogaster)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Drosophila melanogaster)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Drosophila melanogaster)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
UCH proteinases (Drosophila melanogaster)
UCHL1, UCHL3 cleave ubiquitin adducts (Drosophila melanogaster)
UCHL1,UCHL3:Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-specific processing proteases (Drosophila melanogaster)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
USP34 deubiquitinates AXIN1,AXIN2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
USP5 cleaves polyubiquitin (Drosophila melanogaster)
USP5:Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
USP9X (FAM) binds to ubiquitinated SMAD4 (Drosophila melanogaster)
Ub-SMAD4 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-SMAD4:USP9X [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-SMAD4:USP9X [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Drosophila melanogaster)
UBE2D1,2,3:Ubiquitin [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Protein ubiquitination (Drosophila melanogaster)
E3 ubiquitin ligases ubiquitinate target proteins (Drosophila melanogaster)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:PEX5L [peroxisomal membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Drosophila melanogaster)
UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
UBA1 conjugates ubiquitin to UBA1 in the cytosol (Drosophila melanogaster)
Ub-Cys632-UBA1 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Drosophila melanogaster)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Drosophila melanogaster)
Ub-Cys632-UBA1 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:E2 (UBA1 substrate) [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-Cys632-UBA1 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Drosophila melanogaster)
Ub-Cys632-UBA1 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Protein localization (Drosophila melanogaster)
Peroxisomal protein import (Drosophila melanogaster)
PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:PEX5L [peroxisomal membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:PEX5L [peroxisomal membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
USP9X binds Ub:PEX5L (Drosophila melanogaster)
USP9X:Ub:PEX5L [cytosol] (Drosophila melanogaster)
Ub:PEX5L [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:PEX5L [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Drosophila melanogaster)
USP9X:Ub:PEX5L [cytosol] (Drosophila melanogaster)
Ub:PEX5L [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Death Receptor Signalling (Drosophila melanogaster)
p75 NTR receptor-mediated signalling (Drosophila melanogaster)
p75NTR signals via NF-kB (Drosophila melanogaster)
NF-kB is activated and signals survival (Drosophila melanogaster)
IkB is ubiquitinated and degraded (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitinated phospho-IkB [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN localization (Drosophila melanogaster)
PTEN undergoes monoubiquitination (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Regulation of PTEN stability and activity (Drosophila melanogaster)
MKRN1 polyubiquitinates PTEN (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Proteasome degrades polyubiquitinated PTEN (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
RNF146 polyubiquitinates PARylated PTEN (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
USP13 and OTUD3 deubiquitinate PTEN (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog 'off' state (Drosophila melanogaster)
Degradation of GLI1 by the proteasome (Drosophila melanogaster)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
GLI3 is processed to GLI3R by the proteasome (Drosophila melanogaster)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Hedgehog 'on' state (Drosophila melanogaster)
NUMB:ITCH ubiquitinates GLI1 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ub-GLI is degraded by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Hedgehog ligand biogenesis (Drosophila melanogaster)
Hh C-terminal fragments are degraded by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
SYVN1 ubiquitinates Hh C-terminal fragments (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by NOTCH (Drosophila melanogaster)
Signaling by NOTCH1 (Drosophila melanogaster)
Activated NOTCH1 Transmits Signal to the Nucleus (Drosophila melanogaster)
ITCH ubiquitinates DTX (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-DTX:ITCH [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by Non-Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by PTK6 (Drosophila melanogaster)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Drosophila melanogaster)
CBL autoubiquitinates (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
CBL binds and ubiquitinates phosphorylated Sprouty (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Drosophila melanogaster)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
CBL ubiquitinates Sprouty (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Drosophila melanogaster)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
CBL-mediated ubiquitination of CIN85 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitination of stimulated EGFR (CBL) (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
Downregulation of ERBB2 signaling (Drosophila melanogaster)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
CUL5 mediates ubiquitination of ERBB2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Downregulation of ERBB2:ERBB3 signaling (Drosophila melanogaster)
RNF41 ubiquitinates ERBB3 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-ERBB3 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
RNF41 ubiquitinates activated ERBB3 (Drosophila melanogaster)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Self-ubiquitination of RNF41 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-RNF41 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by ERBB4 (Drosophila melanogaster)
Downregulation of ERBB4 signaling (Drosophila melanogaster)
ERBB4 ubiquitination by WWP1/ITCH (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Negative regulation of FGFR1 signaling (Drosophila melanogaster)
CBL ubiquitinates FRS2 and FGFR1 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by FGFR2 (Drosophila melanogaster)
Negative regulation of FGFR2 signaling (Drosophila melanogaster)
CBL ubiquitinates FRS2 and FGFR2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by FGFR3 (Drosophila melanogaster)
Negative regulation of FGFR3 signaling (Drosophila melanogaster)
CBL ubiquitinates FRS2 and FGFR3 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by FGFR4 (Drosophila melanogaster)
Negative regulation of FGFR4 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by TGF-beta family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
TGF-beta receptor signaling activates SMADs (Drosophila melanogaster)
Downregulation of TGF-beta receptor signaling (Drosophila melanogaster)
Degradation of TGF-beta receptor complex (Drosophila melanogaster)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Degradation of ubiquitinated SMAD2 (Drosophila melanogaster)
Ub-SMAD2 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Degradation of ubiquitinated SMAD3 (Drosophila melanogaster)
Ub-SMAD3 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
SMURF2 ubiquitinates SMAD2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-SMAD2 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
STUB1 (CHIP) ubiquitinates SMAD3 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-SMAD3 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Drosophila melanogaster)
Disassembly of tight junctions (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
USP9X (FAM) binds to ubiquitinated SMAD4 (Drosophila melanogaster)
Ub-SMAD4 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-SMAD4:USP9X [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-SMAD4:USP9X [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Drosophila melanogaster)
Ub-SMAD4 [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
Beta-catenin independent WNT signaling (Drosophila melanogaster)
PCP/CE pathway (Drosophila melanogaster)
Asymmetric localization of PCP proteins (Drosophila melanogaster)
SMURF1/2 ubiquitinates PRICKLE1 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Degradation of beta-catenin by the destruction complex (Drosophila melanogaster)
Degradation of ubiquitinated beta catenin by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
TCF dependent signaling in response to WNT (Drosophila melanogaster)
Degradation of AXIN (Drosophila melanogaster)
AXIN is ubiquitinated by SMURF2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
RNF146 ubiquitinates ADP-ribosylated AXIN (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-RibC-AXIN is degraded by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitinated AXIN is degraded by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Degradation of DVL (Drosophila melanogaster)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
DVL1 is ubiquitinated by HECW1 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ubiquitinated DVL1 is degraded by the proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
USP34 deubiquitinates AXIN1,AXIN2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Transport of small molecules (Drosophila melanogaster)
ABC-family proteins mediated transport (Drosophila melanogaster)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Drosophila melanogaster)
Ub-misfolded nascent CFTR [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
misfolded CFTR is degraded by the 26S proteasome (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Ub-misfolded nascent CFTR [cytosol] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Iron uptake and transport (Drosophila melanogaster)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
BAR domain proteins recruit dynamin (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
Epsin family proteins bind ubiquitinated cargo (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Clathrin recruits PIK3C2A (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Clathrin recruits auxilins to the clathrin-coated vesicle (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Ub [cytosol] (Drosophila melanogaster)
Participants
members
Homologues of RPS27A(1-76) [cytosol] (Drosophila melanogaster)
UBI-P63E 12 [cytosol] (Drosophila melanogaster)
UBI-P63E 1 [cytosol] (Drosophila melanogaster)
UBI-P63E 2 [cytosol] (Drosophila melanogaster)
UBI-P63E 3 [cytosol] (Drosophila melanogaster)
UBC(1-76) [cytosol] (Drosophila melanogaster)
UBC(77-152) [cytosol] (Drosophila melanogaster)
UBC(153-228) [cytosol] (Drosophila melanogaster)
UBC(229-304) [cytosol] (Drosophila melanogaster)
UBC(305-380) [cytosol] (Drosophila melanogaster)
UBC(381-456) [cytosol] (Drosophila melanogaster)
UBC(457-532) [cytosol] (Drosophila melanogaster)
UBC(533-608) [cytosol] (Drosophila melanogaster)
UBC(609-684) [cytosol] (Drosophila melanogaster)
Participant Of
hasComponent
E1 bound ubiquitin [cytosol]
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane]
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane]
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
geminin:ubiquitin complex [cytosol]
K63 linked polyubiquitin chain [cytosol]
multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol]
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol]
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol]
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol]
Multiubiquitinated Nek2A [cytosol]
multiubiquitinated Skp2:phospho-APC/C:Cdh1 complex [cytosol]
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol]
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane]
SCF-associated multiubiquitinated Emi1complexes [cytosol]
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane]
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction]
Ub-(Y55/Y227)p-SPRY2 [plasma membrane]
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane]
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
Ub-Beta-Pix:CDC42:GTP [cytosol]
Ub-Cys632-UBA1 [cytosol]
Ub-DTX:ITCH [cytosol]
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane]
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane]
Ub-ERBB3 [plasma membrane]
Ub-ERBB4:WWP1/ITCH [plasma membrane]
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol]
ub-hydroxyPro-HIF-alpha [cytosol]
Ub-misfolded nascent CFTR [cytosol]
Ub-p-S123-CDC25A [cytosol]
Ub-p-S252,S497,T501-BORA [cytosol]
Ub-p-Y53/55-SPRY1/2 [cytosol]
Ub-RNF41 [cytosol]
Ub-SMAD2 [cytosol]
Ub-SMAD3 [cytosol]
Ub-SMAD4 [cytosol]
Ub-SMAD4:USP9X [cytosol]
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol]
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment]
Ub:E2 (UBA1 substrate) [cytosol]
Ub:PEX5L [cytosol]
Ub:PEX5L [peroxisomal membrane]
Ub:substrate [cytosol]
Ub:UBE2D1,2,3 [cytosol]
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol]
Ub:UBE2L3 [cytosol]
Ub:UBE2N [cytosol]
Ub:UBE2N:UBE2V1 [cytosol]
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane]
UBE2D1,2,3:Ubiquitin [cytosol]
Ubiquitin:E2 conjugating enzymes [cytosol]
ubiquitinated Cdc6 [cytosol]
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol]
Ubiquitinated phospho-IkB [cytosol]
UCHL1,UCHL3:Ub [cytosol]
USP5:Ub [cytosol]
input
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
Activated TRAF6 synthesizes unanchored polyubiquitin chains
AUF1 (hnRNP D0) is ubiquitinylated
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2
AXIN is ubiquitinated by SMURF2
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex
CBL autoubiquitinates
CBL binds and ubiquitinates phosphorylated Sprouty
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
CBL ubiquitinates FRS2 and FGFR1
CBL ubiquitinates FRS2 and FGFR2
CBL ubiquitinates FRS2 and FGFR3
CBL ubiquitinates Sprouty
CBL-mediated ubiquitination of CIN85
CHIP (STUB1) mediates ubiquitination of ERBB2
CUL5 mediates ubiquitination of ERBB2
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
DVL is ubiquitinated by CUL3:KLHL12:RBX1
DVL1 is ubiquitinated by HECW1
E1 mediated ubiquitin activation
ERBB4 ubiquitination by WWP1/ITCH
IkB is ubiquitinated and degraded
ITCH polyubiquitinates TP73
ITCH ubiquitinates DTX
MKRN1 polyubiquitinates PTEN
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
Multiubiquitination of Nek2A
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
NUMB:ITCH ubiquitinates GLI1
Parkin promotes the ubiquitination of mitochondrial substrates
Phosphorylated SPRY2 is ubiquitinated by CBL
PTEN undergoes monoubiquitination
RNF146 polyubiquitinates PARylated PTEN
RNF146 ubiquitinates ADP-ribosylated AXIN
RNF41 ubiquitinates activated ERBB3
RNF41 ubiquitinates ERBB3
RNF5 and RNF185 ubiquitinate misfolded CFTR
SCF(beta-TrCP) ubiquitinates p-GLI1
SCF(beta-TrCP) ubiquitinates p-GLI3
SCF-FBXL18 ubiquitinates FBXL7
SCF-FBXL7 ubiquitinates AURKA
Self-ubiquitination of RNF41
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2
SMURF1/2 ubiquitinates PRICKLE1
SMURF2 ubiquitinates SMAD2
STUB1 (CHIP) ubiquitinates SMAD3
STUB1 polyubiquitinates RUNX2
SYVN1 ubiquitinates Hh C-terminal fragments
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol
UBA1 adenylates ubiquitin in the cytosol
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
Ubiquitination of Cyclin A by APC/C:Cdc20 complex
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
Ubiquitination of stimulated EGFR (CBL)
Ubiquitination of stimulated EGFR (CBL:GRB2)
output
26S proteasome degrades TP73 polyubiquitinated by ITCH
26S proteasome processes p-7S-p100:RELB to form p52:RELB
APC/C:Cdh1-mediated degradation of Skp2
Degradation multiubiquitinated Cyclin A
Degradation of multiubiquitinated cell cycle proteins
Degradation of multiubiquitinated Cyclin B
Degradation of multiubiquitinated Nek2A
Degradation of multiubiquitinated Securin
Degradation of ubiquitinated beta catenin by the proteasome
Hh C-terminal fragments are degraded by the proteasome
misfolded CFTR is degraded by the 26S proteasome
Polyubiquitinated RUNX3 is degraded by the proteasome
Proteasomal cleavage of substrate
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
Proteasome degrades polyubiquitinated PTEN
Proteasome mediated degradation of Cyclin D1
Proteasome proteolyzes ub-HIF-alpha
Proteasome-mediated degradation of PolyUb-FBXL7
Proteolytic degradation of ubiquitinated-Cdc25A
ub-GLI is degraded by the proteasome
Ub-RibC-AXIN is degraded by the proteasome
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
Ubiquitinated AXIN is degraded by the proteasome
Ubiquitinated Cdc6 is degraded by the proteasome
Ubiquitinated DVL1 is degraded by the proteasome
Ubiquitinated geminin is degraded by the proteasome
Ubiquitinated Orc1 is degraded by the proteasome
USP13 and OTUD3 deubiquitinate PTEN
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
USP33 deubiquitinates ROBO1
USP34 deubiquitinates AXIN1,AXIN2
USP5 cleaves polyubiquitin
USP9X (FAM) deubiquitinates SMAD4
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin
Inferred From
Ub [cytosol] (Homo sapiens)
© 2019
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