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phospho-p-S317,S345-CHEK1 [nucleoplasm]
Stable Identifier
R-DME-113838
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
O61661
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle Checkpoints (Drosophila melanogaster)
G1/S DNA Damage Checkpoints (Drosophila melanogaster)
p53-Independent G1/S DNA damage checkpoint (Drosophila melanogaster)
p53-Independent DNA Damage Response (Drosophila melanogaster)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Drosophila melanogaster)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Drosophila melanogaster)
G2/M Checkpoints (Drosophila melanogaster)
Activation of ATR in response to replication stress (Drosophila melanogaster)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Drosophila melanogaster)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Drosophila melanogaster)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Drosophila melanogaster)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Drosophila melanogaster)
Recruitment and activation of Chk1 (Drosophila melanogaster)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Drosophila melanogaster)
G2/M DNA damage checkpoint (Drosophila melanogaster)
CHEK1 phosphorylates TP53 (Drosophila melanogaster)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Drosophila melanogaster)
Recruitment and activation of Chk1 (Drosophila melanogaster)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Drosophila melanogaster)
DNA Repair (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Drosophila melanogaster)
HDR through Homologous Recombination (HRR) (Drosophila melanogaster)
Homologous DNA Pairing and Strand Exchange (Drosophila melanogaster)
Presynaptic phase of homologous DNA pairing and strand exchange (Drosophila melanogaster)
CHEK1 phosphorylates RAD51 (Drosophila melanogaster)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Drosophila melanogaster)
Processing of DNA double-strand break ends (Drosophila melanogaster)
Activation of CHEK1 at resected DNA DSBs (Drosophila melanogaster)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by E2F6 (Drosophila melanogaster)
CHEK1 phosphorylates E2F6 (Drosophila melanogaster)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
Regulation of TP53 Activity (Drosophila melanogaster)
Regulation of TP53 Activity through Phosphorylation (Drosophila melanogaster)
CHEK1 phosphorylates TP53 (Drosophila melanogaster)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O61661
Reference Genes
BioGPS Gene:34993
ENSEMBL:FBgn0261278
FlyBase:FBgn0261278
KEGG:dme:Dmel_CG17161
Monarch:34993
NCBI Gene:34993
UCSC:O61661
Reference Transcript
RefSeq:NM_165172.3
RefSeq:NM_057663.4
RefSeq:NM_165171.3
Other Identifiers
154999_at
1632423_at
1634230_s_at
34993
GO:0000077
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006325
GO:0006338
GO:0006468
GO:0006974
GO:0007010
GO:0007348
GO:0016740
GO:0033314
GO:0035402
GO:0035556
GO:0042060
GO:0043226
GO:0051225
GO:0051299
GO:0051726
GO:0106310
GO:0140096
Participates
as an output of
Recruitment and activation of Chk1 (Drosophila melanogaster)
Activation of CHEK1 at resected DNA DSBs (Drosophila melanogaster)
Other forms of this molecule
CHEK1 [cytosol]
CHEK1 [nucleoplasm]
Inferred From
p-S317,S345-CHEK1 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 317 (in Homo sapiens)
Coordinate
317
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 345 (in Homo sapiens)
Coordinate
345
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_477011.1
,
NP_723986.1
,
NP_723985.1
ENSEMBL
FBtr0080885
,
FBtr0080886
,
FBtr0080884
,
FBpp0080442
,
FBpp0080441
,
FBpp0080443
PRO
O61661
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