Reactome | p-T,Y MAPK dimers [cytosol]

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to heat stress (Drosophila melanogaster)
    - Regulation of HSF1-mediated heat shock response (Drosophila melanogaster)
      - Constitutive phosphorylation by pERK1/2 (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)

Developmental Biology (Drosophila melanogaster)

- MITF-M-regulated melanocyte development (Drosophila melanogaster)
  - Transcriptional and post-translational regulation of MITF-M expression and activity (Drosophila melanogaster)
    - MAPK-dependent phosphorylation of KARS (Drosophila melanogaster)
      - p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
- Signaling by NODAL (Drosophila melanogaster)
  - The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)
    - p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
      - Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
        
        MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
        
        The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)

Immune System (Drosophila melanogaster)

- Cytokine Signaling in Immune system (Drosophila melanogaster)
  - Interferon Signaling (Drosophila melanogaster)
    - Interferon gamma signaling (Drosophila melanogaster)
      - JAK2-activated MAPKs phosphorylate YBX1 (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
- Innate Immune System (Drosophila melanogaster)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Drosophila melanogaster)
    - Regulation of actin dynamics for phagocytic cup formation (Drosophila melanogaster)
      - p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)

Programmed Cell Death (Drosophila melanogaster)

- Apoptosis (Drosophila melanogaster)
  - Intrinsic Pathway for Apoptosis (Drosophila melanogaster)
    - Apoptotic factor-mediated response (Drosophila melanogaster)
      - Cytochrome c-mediated apoptotic response (Drosophila melanogaster)
        
        Formation of apoptosome (Drosophila melanogaster)
        
        Regulation of the apoptosome activity (Drosophila melanogaster)
        
        CASP9 is phosphorylated at T412 (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- MAPK family signaling cascades (Drosophila melanogaster)
  - MAPK1/MAPK3 signaling (Drosophila melanogaster)
    - RAF-independent MAPK1/3 activation (Drosophila melanogaster)
      - Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
      - Phosphorylated MAPKs translocate into the nucleus (Drosophila melanogaster)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
      - p-T,Y MAPKs dimerize (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
    - RAF/MAP kinase cascade (Drosophila melanogaster)
      - Negative regulation of MAPK pathway (Drosophila melanogaster)
        
        Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
        
        Negative feedback regulation of MAPK pathway (Drosophila melanogaster)
        
        Activated MAPK phosphorylates RAF1 (Drosophila melanogaster)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
        
        Activated MAPKs phosphorylate BRAF (Drosophila melanogaster)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
        
        Activated MAPKs phosphorylate MAP2K1 (Drosophila melanogaster)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
        
        PTPN7 binds p-T,Y-MAPK (Drosophila melanogaster)
        
        PTPN7:p-T,Y-MAPK dimers [cytosol] (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
        
        PTPN7 dephosphorylates p-T,Y-MAPKs (Drosophila melanogaster)
        
        PTPN7:p-T,Y-MAPK dimers [cytosol] (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
      - Phosphorylated MAPKs translocate into the nucleus (Drosophila melanogaster)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
      - p-T,Y MAPKs dimerize (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
- Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
  - Signaling by FGFR (Drosophila melanogaster)
    - Signaling by FGFR1 (Drosophila melanogaster)
      - Negative regulation of FGFR1 signaling (Drosophila melanogaster)
        
        Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
        
        Spry regulation of FGF signaling (Drosophila melanogaster)
        
        SPRY2 is serine phosphorylated in response to MAPK activation (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
    - Signaling by FGFR2 (Drosophila melanogaster)
      - Negative regulation of FGFR2 signaling (Drosophila melanogaster)
        
        Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
        
        Spry regulation of FGF signaling (Drosophila melanogaster)
        
        SPRY2 is serine phosphorylated in response to MAPK activation (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
    - Signaling by FGFR3 (Drosophila melanogaster)
      - Negative regulation of FGFR3 signaling (Drosophila melanogaster)
        
        Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
        
        Spry regulation of FGF signaling (Drosophila melanogaster)
        
        SPRY2 is serine phosphorylated in response to MAPK activation (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
    - Signaling by FGFR4 (Drosophila melanogaster)
      - Negative regulation of FGFR4 signaling (Drosophila melanogaster)
        
        Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
        
        Spry regulation of FGF signaling (Drosophila melanogaster)
        
        SPRY2 is serine phosphorylated in response to MAPK activation (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
  - Signaling by NTRKs (Drosophila melanogaster)
    - Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
      - Signalling to ERKs (Drosophila melanogaster)
        
        Prolonged ERK activation events (Drosophila melanogaster)
        
        Frs2-mediated activation (Drosophila melanogaster)
        
        p-T,Y MAPK dimers translocate to nucleus (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
        
        p-T,Y MAPKs dimerize (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
  - Signaling by Rho GTPases (Drosophila melanogaster)
    - RHO GTPase Effectors (Drosophila melanogaster)
      - RHO GTPases Activate WASPs and WAVEs (Drosophila melanogaster)
        
        p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
- Signaling by TGFB family members (Drosophila melanogaster)
  - Signaling by Activin (Drosophila melanogaster)
    - The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)
      - p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
  - Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
      - Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
        
        MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
        
        The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)
        
        p-T,Y MAPK dimers [cytosol] (Drosophila melanogaster)