Reactome | Cdk4 [nucleoplasm]

Cdk4 [nucleoplasm]

Stable Identifier

R-DME-141283

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

CDK6, Q7K306

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle, Mitotic (Drosophila melanogaster)
  - Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
    - G1 Phase (Drosophila melanogaster)
      - Cyclin D associated events in G1 (Drosophila melanogaster)
        
        CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Drosophila melanogaster)
        
        CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Drosophila melanogaster)
        
        CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Drosophila melanogaster)
        
        CDK4/6:CCND [nucleoplasm] (Drosophila melanogaster)
        
        CDK4,CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Cdk4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK4/6:CCND [nucleoplasm] (Drosophila melanogaster)
        
        CDK4,CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Cdk4 [nucleoplasm] (Drosophila melanogaster)
        
        Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Drosophila melanogaster)
        
        CDK4,CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Cdk4 [nucleoplasm] (Drosophila melanogaster)
        
        Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Drosophila melanogaster)
        
        CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Drosophila melanogaster)
        
        CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Drosophila melanogaster)
        
        CDK4/6:CCND [nucleoplasm] (Drosophila melanogaster)
        
        CDK4,CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Cdk4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK4/6:CCND [nucleoplasm] (Drosophila melanogaster)
        
        CDK4,CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Cdk4 [nucleoplasm] (Drosophila melanogaster)
        
        Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Drosophila melanogaster)
        
        CDK4,CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Cdk4 [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional regulation by RUNX1 (Drosophila melanogaster)
      - Regulation of RUNX1 Expression and Activity (Drosophila melanogaster)
        
        CDK6 binds RUNX1 (Drosophila melanogaster)
        
        Homologues of CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Cdk4 [nucleoplasm] (Drosophila melanogaster)
        
        RUNX1,RUNX1:CBFB:CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CDK6 [nucleoplasm] (Drosophila melanogaster)
        
        Cdk4 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q7K306

Gene Names

Cdk4

Reference Genes

BioGPS Gene:36854 Cdk4

ENSEMBL:FBgn0016131

Flybase:FBgn0016131

KEGG Gene (Drosophila melanogaster):Dmel_CG5072 Cdk4

Monarch:36854 Cdk4

NCBI Gene:36854 Cdk4

UCSC:Q7K306 Cdk4

Reference Transcript

Other Identifiers

154563_at

1639347_s_at

36854

GO:0000166

GO:0003674

GO:0004672

GO:0004674

GO:0004693

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006464

GO:0006468

GO:0007005

GO:0007049

GO:0007165

GO:0007350

GO:0007424

GO:0008150

GO:0008283

GO:0008353

GO:0009790

GO:0010821

GO:0016301

GO:0016310

GO:0016592

GO:0016740

GO:0030307

GO:0030332

GO:0032991

GO:0040007

GO:0043167

GO:0043226

GO:0046427

GO:0048856

GO:0051726

GO:1904263

Participant Of

hasMember

Homologues of CDK6 [nucleoplasm]

Other forms of this molecule

Cdk4 [cytosol]

Cdk4 [nucleoplasm]

phospho-Cdk4 [nucleoplasm]

Inferred From

CDK6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_725595.1, NP_001286494.1, NP_725594.1, NP_477196.1, NP_001286493.1

Flybase

FBgn0016131

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