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mad2 [cytosol]
Stable Identifier
R-DME-141447
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
Activated MAD2L1, Q9VRQ2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle Checkpoints (Drosophila melanogaster)
Mitotic Spindle Checkpoint (Drosophila melanogaster)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Drosophila melanogaster)
Inactivation of APC/C via CDC20 sequestration (Drosophila melanogaster)
MAD2*CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Inactivation of APC/C via direct inhibition of the APC/C complex (Drosophila melanogaster)
Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Formation of the MCC complex (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Drosophila melanogaster)
APC-Cdc20 mediated degradation of Nek2A (Drosophila melanogaster)
Association of Nek2A with MCC:APC/C (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Degradation of multiubiquitinated Nek2A (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Multiubiquitinated Nek2A [cytosol] (Drosophila melanogaster)
Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Multiubiquitination of Nek2A (Drosophila melanogaster)
Multiubiquitinated Nek2A [cytosol] (Drosophila melanogaster)
Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Drosophila melanogaster)
Association of Cyclin A with the APC/C (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2* complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Regulation of APC/C activators between G1/S and early anaphase (Drosophila melanogaster)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Drosophila melanogaster)
Inactivation of APC/C via CDC20 sequestration (Drosophila melanogaster)
MAD2*CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Inactivation of APC/C via direct inhibition of the APC/C complex (Drosophila melanogaster)
Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)
MCC:APC/C complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
Formation of the MCC complex (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
mad2 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VRQ2
Gene Names
mad2
Reference Genes
BioGPS Gene:38656 mad2
ENSEMBL:FBgn0035640
Flybase:FBgn0035640
KEGG Gene (Drosophila melanogaster):Dmel_CG17498 mad2
Monarch:38656 mad2
NCBI Gene:38656 mad2
UCSC:Q9VRQ2 mad2
Reference Transcript
RefSeq:NM_139734.3 mad2
Other Identifiers
148237_at
1640938_at
38656
GO:0000278
GO:0000776
GO:0000922
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005737
GO:0005819
GO:0005828
GO:0005856
GO:0007010
GO:0007059
GO:0007094
GO:0007346
GO:0022414
GO:0023052
GO:0030154
GO:0043226
GO:0048133
GO:0048856
GO:0051276
GO:0072686
GO:0090266
GO:0140014
GO:1901673
GO:1990047
Participates
as an input of
Inactivation of APC/C via CDC20 sequestration (Drosophila melanogaster)
Formation of the MCC complex (Drosophila melanogaster)
as a component of
MAD2*CDC20 complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2* complex [cytosol] (Drosophila melanogaster)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Drosophila melanogaster)
Inferred From
Activated MAD2L1 [cytosol]
(Homo sapiens)
MAD2L1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_647991.1
Flybase
FBgn0035640
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