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phospho-Cdk1 [cytosol]
Stable Identifier
R-DME-157415
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
p-T161-CDK1, P23572
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Prometaphase (Drosophila melanogaster)
Resolution of Sister Chromatid Cohesion (Drosophila melanogaster)
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Drosophila melanogaster)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Mitotic Prophase (Drosophila melanogaster)
Nuclear Envelope Breakdown (Drosophila melanogaster)
Nuclear Pore Complex (NPC) Disassembly (Drosophila melanogaster)
CDK1 phosphorylates NUP98 (Drosophila melanogaster)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
Cyclin A/B1/B2 associated events during G2/M transition (Drosophila melanogaster)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Phosphorylation of Cyclin B1 in the CRS domain (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
CRS kinase [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Drosophila melanogaster)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Drosophila melanogaster)
cytoplasmic Cyclin B1:Cdc2 complexes [cytosol] (Drosophila melanogaster)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Regulation of PLK1 Activity at G2/M Transition (Drosophila melanogaster)
CDK1 phosphorylates BORA (Drosophila melanogaster)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of Cyclin B (Drosophila melanogaster)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Drosophila melanogaster)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Drosophila melanogaster)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Drosophila melanogaster)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Drosophila melanogaster)
Association of Cyclin A with the APC/C (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF-independent MAPK1/3 activation (Drosophila melanogaster)
MAPK3 (ERK1) activation (Drosophila melanogaster)
Inactivation of MAP2K1 by CDK1 (Drosophila melanogaster)
phospho-Cdk1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P23572
Gene Names
Cdk1
Reference Genes
BioGPS Gene:34411 Cdk1
ENSEMBL:FBgn0004106
Flybase:FBgn0004106
KEGG Gene (Drosophila melanogaster):Dmel_CG5363 Cdk1
Monarch:34411 Cdk1
NCBI Gene:34411 Cdk1
Reference Transcript
RefSeq:NM_057449.4 Cdk1
Other Identifiers
154844_at
1631861_at
34411
GO:0000003
GO:0000082
GO:0000086
GO:0000166
GO:0000278
GO:0001700
GO:0003674
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005856
GO:0006259
GO:0006464
GO:0006468
GO:0006950
GO:0007049
GO:0007095
GO:0007140
GO:0007284
GO:0008150
GO:0008283
GO:0008353
GO:0009058
GO:0009790
GO:0016301
GO:0016310
GO:0016740
GO:0030154
GO:0030174
GO:0030707
GO:0032880
GO:0034641
GO:0043167
GO:0043226
GO:0044772
GO:0044818
GO:0045169
GO:0048142
GO:0048646
GO:0048856
GO:0051301
GO:0055059
GO:0072686
GO:1901987
Participant Of
output
Degradation multiubiquitinated Cyclin A
Degradation of multiubiquitinated Cyclin B
hasComponent
CCNB1:p-T161-CDK1 [cytosol]
CCNB2:p-T161-CDK1 [cytosol]
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol]
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol]
Other forms of this molecule
Cdk1 [cytosol]
phospho-Cdk1 [nucleoplasm]
phospho-Cdk1 [cytosol]
phospho-Cdk1 [cytosol]
phospho-Cdk1 [nucleoplasm]
phospho-Cdk1 [nucleoplasm]
phospho-Cdk1 [nucleoplasm]
Inferred From
p-T161-CDK1 [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 161 (in Homo sapiens)
Coordinate
161
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_476797.1
Flybase
FBgn0004106
IntEnz
2.7.11.22
PRO
P23572
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54733
4
CycE [cytosol]
(R-DME-157443)
CycE [cytosol]
(R-DME-157452)
CycE [nucleoplasm]
(R-DME-68367)
CycE [nucleoplasm]
(R-DME-68363)
0.785
6
UniProt:Q9VHN1 Q9VHN1
0.621
4
UniProt:Q03019
12
phospho-twe [nucleoplasm]
(R-DME-6802968-2)
twe [cytosol]
(R-DME-6782810-2)
phospho-twe [cytosol]
(R-DME-69588-2)
phospho-twe [cytosol]
(R-DME-8981697-2)
twe [cytosol]
(R-DME-157410-2)
phospho-twe [nucleoplasm]
(R-DME-156668-2)
phospho-twe [nucleoplasm]
(R-DME-143488-2)
twe [nucleoplasm]
(R-DME-143487-2)
twe [cytosol]
(R-DME-157879-2)
phospho-twe [cytosol]
(R-DME-75003-2)
phospho-twe [nucleoplasm]
(R-DME-156496-2)
twe [nucleoplasm]
(R-DME-69741-2)
0.621
4
UniProt:P25008
1
CycC [nucleoplasm]
(R-DME-212418)
0.621
4
UniProt:Q961D1
1
CycK [nucleoplasm]
(R-DME-6796619)
0.621
4
UniProt:P14785
6
CycA [nucleoplasm]
(R-DME-6783068)
CycA [nucleoplasm]
(R-DME-6783099)
CycA [cytosol]
(R-DME-157444)
CycA [cytosol]
(R-DME-157446)
CycA [nucleoplasm]
(R-DME-68891)
CycA [nucleoplasm]
(R-DME-68905)
0.534
2
UniProt:Q9I7I0 CCNB3
0.499
2
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