Drosophila NICD traffics to nucleus

Stable Identifier
R-DME-159111
Type
Reaction
Species
Drosophila melanogaster
Compartment
Summation

NICD translocates to the nucleus and assembles into a ternary complex with the CSL (human RBPJ i.e. CBF1/ fly Suppressor of Hairless/ worm Lag1) DNA-binding protein and the Mastermind co-activator. This complex activates the transcription of downstream gene targets like HES (Hairy/Enhancer of Split) and HES-related (HRT, also named CHF, HEY, HESR, gridlock) genes.

Literature References
Participants
Orthologous Events