Reactome | tsu [cytosol]

tsu [cytosol]

Stable Identifier

R-DME-162462

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

RBM8A, Q9V535

Locations in the PathwayBrowser

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Metabolism of RNA (Drosophila melanogaster)

- Nonsense-Mediated Decay (NMD) (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Drosophila melanogaster)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Drosophila melanogaster)
        
        Magoh-Y14 complex [cytosol] (Drosophila melanogaster)
        
        tsu [cytosol] (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Drosophila melanogaster)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Drosophila melanogaster)
        
        Magoh-Y14 complex [cytosol] (Drosophila melanogaster)
        
        tsu [cytosol] (Drosophila melanogaster)
    - SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Drosophila melanogaster)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Drosophila melanogaster)
        
        Magoh-Y14 complex [cytosol] (Drosophila melanogaster)
        
        tsu [cytosol] (Drosophila melanogaster)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Drosophila melanogaster)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Drosophila melanogaster)
        
        Magoh-Y14 complex [cytosol] (Drosophila melanogaster)
        
        tsu [cytosol] (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Drosophila melanogaster)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Drosophila melanogaster)
        
        Magoh-Y14 complex [cytosol] (Drosophila melanogaster)
        
        tsu [cytosol] (Drosophila melanogaster)
- Processing of Capped Intron-Containing Pre-mRNA (Drosophila melanogaster)
  - Transport of Mature Transcript to Cytoplasm (Drosophila melanogaster)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Drosophila melanogaster)
      - Transport of the export-competent mRNP complex through the NPC (Drosophila melanogaster)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Drosophila melanogaster)
        
        EJC [cytosol] (Drosophila melanogaster)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Drosophila melanogaster)
        
        Magoh-Y14 complex [cytosol] (Drosophila melanogaster)
        
        tsu [cytosol] (Drosophila melanogaster)
      - mRNP complex dissociates from cytosolic face of NPC (Drosophila melanogaster)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Drosophila melanogaster)
        
        EJC [cytosol] (Drosophila melanogaster)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Drosophila melanogaster)
        
        Magoh-Y14 complex [cytosol] (Drosophila melanogaster)
        
        tsu [cytosol] (Drosophila melanogaster)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Drosophila melanogaster)
        
        EJC [cytosol] (Drosophila melanogaster)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Drosophila melanogaster)
        
        Magoh-Y14 complex [cytosol] (Drosophila melanogaster)
        
        tsu [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9V535

Gene Names

tsu

Reference Genes

BioGPS Gene:35924 tsu

ENSEMBL:FBgn0033378

Flybase:FBgn0033378

KEGG Gene (Drosophila melanogaster):Dmel_CG8781 tsu

Monarch:35924 tsu

NCBI Gene:35924 tsu

UCSC:Q9V535 tsu

Reference Transcript

RefSeq:NM_136610.4 tsu

Other Identifiers

146865_at

1623902_at

35924

GO:0000226

GO:0000398

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006396

GO:0006397

GO:0006913

GO:0007010

GO:0007294

GO:0007310

GO:0007314

GO:0007317

GO:0008380

GO:0016071

GO:0016607

GO:0022414

GO:0030154

GO:0035145

GO:0042564

GO:0043226

GO:0045451

GO:0046595

GO:0048856

GO:0051028

GO:0051168

GO:0051170

GO:0051663

GO:0071013

GO:0110165

GO:1990501

Participates

as a component of

Magoh-Y14 complex [cytosol] (Drosophila melanogaster)

Other forms of this molecule

tsu [nucleoplasm]

Inferred From

RBM8A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_610454.2

Flybase

FBgn0033378

PRO

Q9V535

PDB

1OO0, 1RK8, 2X1G, 1HL6

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