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Lst8 [cytosol]
Stable Identifier
R-DME-165676
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
MLST8, Q9W328
Locations in the PathwayBrowser
Expand all
Autophagy (Drosophila melanogaster)
Macroautophagy (Drosophila melanogaster)
Active MTORC1 binds the ULK1 complex (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Active MTORC1 phosphorylates ULK1 (Drosophila melanogaster)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
MTORC1 dissociates from ULK complex (Drosophila melanogaster)
MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Rheb in the MTORC1 complex hydrolyses GTP (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Drosophila melanogaster)
MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to mechanical stimuli (Drosophila melanogaster)
Response of endothelial cells to shear stress (Drosophila melanogaster)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Drosophila melanogaster)
mTORC2 phosphorylates AKT1 on serine-473 (Drosophila melanogaster)
TORC2 complex [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to starvation (Drosophila melanogaster)
Amino acids regulate mTORC1 (Drosophila melanogaster)
RRAGA,B hydrolyzes GTP (Drosophila melanogaster)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1 binds RHEB:GTP (Drosophila melanogaster)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Metabolic Genes (Drosophila melanogaster)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Regulation of T cell activation by CD28 family (Drosophila melanogaster)
Co-stimulation by CD28 (Drosophila melanogaster)
CD28 dependent PI3K/Akt signaling (Drosophila melanogaster)
TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)
TORC2 complex [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN gene transcription (Drosophila melanogaster)
MAF1 translocates to the nucleus (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1 phosphorylates MAF1 (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)
TORC2 complex [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
MTOR signalling (Drosophila melanogaster)
AKT1S1 (PRAS40) binds mTORC1 (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Energy dependent regulation of mTOR by LKB1-AMPK (Drosophila melanogaster)
AMPK phosphorylates Raptor in the mTORC1 complex (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Formation of active mTORC1 complex (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Phosphorylated AKT1S1:mTORC1 binds YWHAB (Drosophila melanogaster)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Drosophila melanogaster)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1 phosphorylates AKT1S1 (Drosophila melanogaster)
mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Drosophila melanogaster)
mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Drosophila melanogaster)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1-mediated signalling (Drosophila melanogaster)
Phosphorylation of 4E-BP1 by activated mTORC1 (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Drosophila melanogaster)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Drosophila melanogaster)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Drosophila melanogaster)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Drosophila melanogaster)
Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)
TORC2 complex [cytosol] (Drosophila melanogaster)
Lst8 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9W328
Gene Names
Lst8
Reference Genes
BioGPS Gene:31903 Lst8
ENSEMBL:FBgn0264691
FlyBase:FBgn0264691
KEGG:dme:Dmel_CG3004 Lst8
Monarch:31903 Lst8
NCBI Gene:31903 Lst8
UCSC:Q9W328 Lst8
Reference Transcript
RefSeq:NM_132344.4 Lst8
Other Identifiers
154144_at
1628483_at
31903
GO:0005515
GO:0005737
GO:0006355
GO:0031929
GO:0031931
GO:0031932
GO:0032956
GO:0034504
GO:0038203
GO:0045793
GO:0046628
GO:0051897
GO:0061586
Participates
as a component of
TORC2 complex [cytosol] (Drosophila melanogaster)
mTORC1 [cytosol] (Drosophila melanogaster)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Lst8 [nucleoplasm]
Inferred From
MLST8 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_572572.1
ENSEMBL
FBpp0071303
,
FBtr0071368
PRO
Q9W328
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