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MAP2K4 [cytosol]
Stable Identifier
R-DME-168107
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
O61444
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-17 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
MAP2K4 [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
MAP2K4 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
MAP2K4 [cytosol] (Drosophila melanogaster)
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
MAP2K4 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
MAP2K4 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
MAP2K4 [cytosol] (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
MAP2K4 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
MAP2K4 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
MAP2K4 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
MAP2K4 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O61444
Reference Genes
BioGPS Gene:41020
CTD Gene:41020
ENSEMBL:FBgn0024326
Flybase:FBgn0024326
KEGG Gene (Drosophila melanogaster):Dmel_CG9738
Monarch:41020
NCBI Gene:41020
UCSC:O61444
Reference Transcript
RefSeq:NM_058005.5
RefSeq:NM_001170080.2
RefSeq:NM_001275446.1
Other Identifiers
142758_at
149511_at
1630916_at
41020
GO:0000165
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0005524
GO:0006468
GO:0007254
GO:0008545
GO:0010942
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030424
GO:0033209
GO:0036211
GO:0043068
GO:0048082
GO:0048666
GO:0048856
GO:0140096
Participates
as an input of
Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
Other forms of this molecule
phospho-p-S257,T261-MAP2K4 [cytosol]
Inferred From
MAP2K7,MAP2K4 [cytosol]
(Homo sapiens)
MAP2K4 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001163551.1
,
NP_477353.1
,
NP_001262375.1
Flybase
FBgn0024326
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P92208 bsk
12
BSK [cytosol]
(R-DME-206251)
Phospho BSK [nucleoplasm]
(R-DME-206300)
Phospho BSK [cytosol]
(R-DME-206213)
MAPK8 [cytosol]
(R-DME-168141)
MAPK10 [cytosol]
(R-DME-450352)
MAPK9 [cytosol]
(R-DME-450355)
phospho-p-T183,Y185-MAPK9 [cytosol]
(R-DME-450293)
phospho-p-T,Y-MAPK8 [cytosol]
(R-DME-194371)
phospho-p-T221,Y223-MAPK10 [cytosol]
(R-DME-450214)
phospho-p-T,Y-MAPK8 [nucleoplasm]
(R-DME-216349)
phospho-p-T183,Y185-MAPK9 [nucleoplasm]
(R-DME-450319)
phospho-p-T221,Y223-MAPK10 [nucleoplasm]
(R-DME-450311)
0.502
2
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