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SYT1 [plasma membrane]
Stable Identifier
R-DME-168786
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
plasma membrane
Synonyms
P21521
Locations in the PathwayBrowser
Expand all
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter release cycle (Drosophila melanogaster)
Acetylcholine Neurotransmitter Release Cycle (Drosophila melanogaster)
Release of acetylcholine at the synapse (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
Dopamine Neurotransmitter Release Cycle (Drosophila melanogaster)
Release of docked dopamine loaded synaptic vesicle (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
GABA synthesis, release, reuptake and degradation (Drosophila melanogaster)
Release of GABA at the synapse (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
Glutamate Neurotransmitter Release Cycle (Drosophila melanogaster)
Release of L-Glutamate at the synapse (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
Norepinephrine Neurotransmitter Release Cycle (Drosophila melanogaster)
Release of noradrenaline at the synapse (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
Serotonin Neurotransmitter Release Cycle (Drosophila melanogaster)
Release of docked serotonin loaded synaptic vesicle (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
BAR domain proteins recruit dynamin (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
STON2 binds SYT proteins (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
Clathrin recruits PIK3C2A (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
SYT1 [plasma membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P21521
Reference Genes
BioGPS Gene:33473
ENSEMBL:FBgn0004242
FlyBase:FBgn0004242
KEGG:dme:Dmel_CG3139
Monarch:33473
NCBI Gene:33473
UCSC:P21521
Reference Transcript
RefSeq:NM_001298639.1
RefSeq:NM_001273036.1
RefSeq:NM_164501.2
RefSeq:NM_001273037.1
RefSeq:NM_078736.3
RefSeq:NM_164502.2
RefSeq:NM_205897.2
Other Identifiers
142129_at
142499_at
145667_at
151473_i_at
151474_s_at
1628991_at
1635102_at
1635897_at
1636345_s_at
33473
GO:0000149
GO:0001786
GO:0005509
GO:0005515
GO:0005544
GO:0005886
GO:0007268
GO:0007269
GO:0007317
GO:0008021
GO:0008289
GO:0008345
GO:0014059
GO:0016020
GO:0016079
GO:0016192
GO:0017156
GO:0017158
GO:0019905
GO:0023052
GO:0030276
GO:0030424
GO:0030672
GO:0031045
GO:0031340
GO:0031410
GO:0031594
GO:0033299
GO:0035002
GO:0042803
GO:0043195
GO:0043226
GO:0045202
GO:0046872
GO:0048488
GO:0048791
GO:0050803
GO:0060024
GO:0061024
GO:0061025
GO:0070382
GO:0071277
GO:0150007
GO:1900073
Participates
as a component of
SYT1 dimer [plasma membrane] (Drosophila melanogaster)
as an output of
Release of docked dopamine loaded synaptic vesicle (Drosophila melanogaster)
Release of acetylcholine at the synapse (Drosophila melanogaster)
Release of noradrenaline at the synapse (Drosophila melanogaster)
Release of L-Glutamate at the synapse (Drosophila melanogaster)
Release of GABA at the synapse (Drosophila melanogaster)
Release of docked serotonin loaded synaptic vesicle (Drosophila melanogaster)
Other forms of this molecule
SYT1 [clathrin-coated endocytic vesicle membrane]
SYT2 [clathrin-coated endocytic vesicle membrane]
SYT8 [clathrin-coated endocytic vesicle membrane]
SYT8 [plasma membrane]
SYT2 [plasma membrane]
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
Inferred From
SYT1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001259965.1
,
NP_001259966.1
,
NP_001285568.1
,
NP_523460.2
,
NP_722838.1
,
NP_722839.1
,
NP_995619.2
ENSEMBL
FBpp0077410
,
FBtr0077726
,
FBgn0004242
FlyBase
FBgn0004242
PRO
P21521
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q24212
4
stnB [cytosol]
(R-DME-8863733)
stnB [cytosol]
(R-DME-8863726)
stnB [cytosol]
(R-DME-8862856)
stnB [cytosol]
(R-DME-8862854)
0.623
5
UniProt:Q24211 STNA
0.499
2
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