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Syt1 [plasma membrane]
Stable Identifier
R-DME-168795
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
plasma membrane
Synonyms
SYT2, P21521
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
BAR domain proteins recruit dynamin (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
STON2 binds SYT proteins (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
Clathrin recruits PIK3C2A (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
SNX9 recruits components of the actin polymerizing machinery (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT dimers [plasma membrane] (Drosophila melanogaster)
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Syt1 [plasma membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P21521
Gene Names
Syt1
Reference Genes
BioGPS Gene:33473 Syt1
ENSEMBL:FBgn0004242
Flybase:FBgn0004242
KEGG Gene (Drosophila melanogaster):Dmel_CG3139 Syt1
Monarch:33473 Syt1
NCBI Gene:33473 Syt1
UCSC:P21521 Syt1
Reference Transcript
RefSeq:NM_164502.2 Syt1
RefSeq:NM_078736.3 Syt1
RefSeq:NM_001273037.1 Syt1
RefSeq:NM_001298639.1 Syt1
RefSeq:NM_164501.2 Syt1
RefSeq:NM_205897.2 Syt1
RefSeq:NM_001273036.1 Syt1
Other Identifiers
33473
GO:0000003
GO:0000149
GO:0001786
GO:0003674
GO:0005509
GO:0005515
GO:0005544
GO:0005575
GO:0005622
GO:0005737
GO:0005886
GO:0006810
GO:0007267
GO:0007268
GO:0007269
GO:0007317
GO:0008021
GO:0008150
GO:0008289
GO:0008345
GO:0009790
GO:0014059
GO:0016020
GO:0016021
GO:0016079
GO:0016192
GO:0017156
GO:0017158
GO:0019905
GO:0021700
GO:0022607
GO:0030054
GO:0030154
GO:0030276
GO:0030285
GO:0030424
GO:0030672
GO:0031045
GO:0031340
GO:0031410
GO:0031594
GO:0042803
GO:0043167
GO:0043195
GO:0043226
GO:0045202
GO:0046872
GO:0048488
GO:0048791
GO:0048856
GO:0050803
GO:0060024
GO:0061024
GO:0070382
GO:0071277
GO:0150007
GO:1900073
Participates
as a component of
SYT2 dimer [plasma membrane] (Drosophila melanogaster)
Other forms of this molecule
Syt1 [clathrin-coated endocytic vesicle membrane]
Syt1 [clathrin-coated endocytic vesicle membrane]
Syt1 [clathrin-coated endocytic vesicle membrane]
Syt1 [plasma membrane]
Syt1 [clathrin-sculpted acetylcholine transport vesicle membrane]
Syt1 [clathrin-sculpted glutamate transport vesicle membrane]
Syt1 [clathrin-sculpted monoamine transport vesicle membrane]
Syt1 [plasma membrane]
Syt1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Inferred From
SYT2 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_722838.1
,
NP_523460.2
,
NP_001259966.1
,
NP_995619.2
,
NP_001285568.1
,
NP_722839.1
,
NP_001259965.1
Flybase
FBgn0004242
PRO
P21521
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q24212
4
stnB [cytosol]
(R-DME-8863726)
stnB [cytosol]
(R-DME-8863733)
stnB [cytosol]
(R-DME-8862856)
stnB [cytosol]
(R-DME-8862854)
0.623
5
UniProt:Q24211 STNA
0.499
2
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