Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Med [cytosol]
Stable Identifier
R-DME-170862
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
SMAD4, O62609
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Signaling by NODAL (Drosophila melanogaster)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
WWTR1:SMAD translocates to the nucleus (Drosophila melanogaster)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Ub-specific processing proteases (Drosophila melanogaster)
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by Activin (Drosophila melanogaster)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
Signaling by BMP (Drosophila melanogaster)
Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Drosophila melanogaster)
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
TGF-beta receptor signaling activates SMADs (Drosophila melanogaster)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
WWTR1:SMAD translocates to the nucleus (Drosophila melanogaster)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
Med [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O62609
Gene Names
Med
Reference Genes
BioGPS Gene:43725 Med
ENSEMBL:FBgn0011655
Flybase:FBgn0011655
KEGG Gene (Drosophila melanogaster):Dmel_CG1775 Med
Monarch:43725 Med
NCBI Gene:43725 Med
UCSC:O62609 Med
Reference Transcript
RefSeq:NM_170560.2 Med
RefSeq:NM_079871.4 Med
Other Identifiers
154087_at
1637202_a_at
43725
GO:0000122
GO:0000977
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0001745
GO:0003677
GO:0005515
GO:0005634
GO:0005667
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0007179
GO:0007476
GO:0007480
GO:0007507
GO:0009653
GO:0009791
GO:0009950
GO:0009953
GO:0022414
GO:0023052
GO:0030154
GO:0030509
GO:0030707
GO:0030718
GO:0031290
GO:0032924
GO:0034330
GO:0035019
GO:0042078
GO:0043226
GO:0045705
GO:0045887
GO:0045944
GO:0046872
GO:0048666
GO:0048856
GO:0050793
GO:0051239
GO:0060395
GO:0070411
GO:0071144
GO:0090571
GO:0140110
Participates
as an input of
Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Drosophila melanogaster)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Drosophila melanogaster)
as a component of
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Drosophila melanogaster)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Drosophila melanogaster)
as an output of
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
Other forms of this molecule
phospho-Med [nucleoplasm]
Med [nucleoplasm]
Med [cytosol]
Med [nucleoplasm]
Inferred From
SMAD4 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_524610.1
,
NP_733439.2
Flybase
FBgn0288966
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text