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eff [nucleoplasm]
Stable Identifier
R-DME-174197
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
UBE2D1, P25867
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
APC/C:Cdh1 polyubiquitinates SKP2 (Drosophila melanogaster)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
Phosphorylation of the APC/C (Drosophila melanogaster)
Free APC/C phosphorylated by Cyclin B:Cdc2 (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Free APC/C phosphorylated by Plk1 (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Autodegradation of Cdh1 by Cdh1:APC/C (Drosophila melanogaster)
Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Drosophila melanogaster)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Multiubiquitination of APC/C-associated Cdh1 (Drosophila melanogaster)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Drosophila melanogaster)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Regulation of APC/C activators between G1/S and early anaphase (Drosophila melanogaster)
Association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Dissociation of phospho-Cdh1 from the APC/C complex (Drosophila melanogaster)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular Senescence (Drosophila melanogaster)
Senescence-Associated Secretory Phenotype (SASP) (Drosophila melanogaster)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Cdh1:APC/C complex binds EHMT1:EHMT2 (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Drosophila melanogaster)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Drosophila melanogaster)
Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Nuclear VBC complex ubiquitinylates HIF-alpha (Drosophila melanogaster)
UBE2D1,2,3:Ubiquitin [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Ovarian tumor domain proteases (Drosophila melanogaster)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Drosophila melanogaster)
OTUB1,(OTUB2):UBE2D1,ESR1 [nucleoplasm] (Drosophila melanogaster)
UBE2D1,ESR1 [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
UBE2D1,ESR1 [nucleoplasm] (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by BMP (Drosophila melanogaster)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Drosophila melanogaster)
eff [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P25867 eff
Gene Names
eff, UbcD1, CG7425
Chain
chain:1-147
Reference Genes
BioGPS Gene:41785 eff
KEGG Gene (Drosophila melanogaster):Dmel_CG7425 eff
Monarch:41785 eff
NCBI Gene:41785 eff
Reference Transcript
RefSeq:NM_001275649.1 eff
RefSeq:NM_169601.2 eff
RefSeq:NM_001275650.1 eff
Other Identifiers
143638_at
1636436_at
41785
GO:0000151
GO:0000166
GO:0000209
GO:0000278
GO:0001745
GO:0001751
GO:0002376
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005829
GO:0006511
GO:0007049
GO:0007140
GO:0016322
GO:0016567
GO:0016740
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030718
GO:0031145
GO:0031625
GO:0031647
GO:0036211
GO:0043226
GO:0045676
GO:0045879
GO:0048132
GO:0048856
GO:0051276
GO:0051301
GO:0051321
GO:0061057
GO:0061631
GO:0097039
GO:0098542
GO:0140013
GO:0140096
Participates
as a member of
UBE2D1,ESR1 [nucleoplasm] (Drosophila melanogaster)
as an output of
Nuclear VBC complex ubiquitinylates HIF-alpha (Drosophila melanogaster)
as a component of
UBE2D1,2,3:Ubiquitin [nucleoplasm] (Drosophila melanogaster)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
EFF [cytosol]
eff [cytosol]
eff [cytosol]
Inferred From
UBE2D1,2,3 [nucleoplasm]
(Homo sapiens)
Nuclear ubiquitin ligase [nucleoplasm]
(Homo sapiens)
UBE2D1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_731941.1
,
NP_001262578.1
,
NP_001262579.1
Flybase
FBgn0011217
PRO
P25867
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:A1Z9I6
1
anon-EST:GressD1 [cytosol]
(R-DME-975976)
0.621
3
UniProt:Q9VHI7
2
Iru [cytosol]
(R-DME-8850904)
Iru [cytosol]
(R-DME-8851642)
0.488
2
UniProt:Q9VNB2 Q9VNB2
0.488
2
UniProt:Q8T3Y0
1
SIAH2 [cytosol]
(R-DME-374566-2)
0.488
2
UniProt:Q7JUV6 Q7JUV6
0.488
2
UniProt:Q9VP20
2
phospho-Mkrn1 [cytosol]
(R-DME-8948758)
Mkrn1 [cytosol]
(R-DME-976042)
0.488
2
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