Reactome | mr [cytosol]

mr [cytosol]

Stable Identifier

R-DME-174229

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

ANAPC2, Q9W1E5

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - Mitotic Spindle Checkpoint (Drosophila melanogaster)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Drosophila melanogaster)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Drosophila melanogaster)
        
        Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
- Cell Cycle, Mitotic (Drosophila melanogaster)
  - M Phase (Drosophila melanogaster)
    - Mitotic Metaphase and Anaphase (Drosophila melanogaster)
      - Mitotic Anaphase (Drosophila melanogaster)
        
        Separation of Sister Chromatids (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Securin (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
  - Regulation of mitotic cell cycle (Drosophila melanogaster)
    - APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Drosophila melanogaster)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Drosophila melanogaster)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Drosophila melanogaster)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Drosophila melanogaster)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Drosophila melanogaster)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        APC/C:Cdc20 mediated degradation of Securin (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Securin (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Drosophila melanogaster)
        
        APC-Cdc20 mediated degradation of Nek2A (Drosophila melanogaster)
        
        Association of Nek2A with MCC:APC/C (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Nek2A (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Multiubiquitinated Nek2A [cytosol] (Drosophila melanogaster)
        
        Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Multiubiquitination of Nek2A (Drosophila melanogaster)
        
        Multiubiquitinated Nek2A [cytosol] (Drosophila melanogaster)
        
        Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Drosophila melanogaster)
        
        Association of Cyclin A with the APC/C (Drosophila melanogaster)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Drosophila melanogaster)
        
        Association of Cdh1 with the APC/C (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        Dissociation of Cdc20 from APC/C complex (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
      - Regulation of APC/C activators between G1/S and early anaphase (Drosophila melanogaster)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Drosophila melanogaster)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Drosophila melanogaster)
        
        Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Synthesis of DNA (Drosophila melanogaster)
      - Switching of origins to a post-replicative state (Drosophila melanogaster)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Drosophila melanogaster)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)

Immune System (Drosophila melanogaster)

- Adaptive Immune System (Drosophila melanogaster)
  - Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
    - Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
      - Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        APC/C E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        APC/C E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
      - Polyubiquitination of substrate (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        APC/C E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        APC/C E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        E3:Ub:substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        APC/C E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
      - Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        APC/C E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        APC/C E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
      - Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        APC/C E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        APC/C E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)
        
        E3:Ub:substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        APC/C E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        mr [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W1E5

Gene Names

Reference Genes

BioGPS Gene:45906 mr

ENSEMBL:FBgn0002791

Flybase:FBgn0002791

KEGG Gene (Drosophila melanogaster):Dmel_CG3060 mr

Monarch:45906 mr

NCBI Gene:45906 mr

UCSC:Q9W1E5 mr

Reference Transcript

RefSeq:NM_138018.3 mr

Other Identifiers

155130_at

1635875_at

45906

GO:0000151

GO:0000278

GO:0005634

GO:0005680

GO:0006511

GO:0007049

GO:0007059

GO:0007091

GO:0023052

GO:0030163

GO:0031145

GO:0031625

GO:0034330

GO:0036211

GO:0043226

GO:0045886

GO:0048856

GO:0050804

GO:0051301

GO:0051726

GO:0070979

Participates

as a component of

Other forms of this molecule

mr [nucleoplasm]

Inferred From

ANAPC2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_611862.1

Flybase

FBgn0002791

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