Reactome | Rad1 [nucleoplasm]

Rad1 [nucleoplasm]

Stable Identifier

R-DME-176382

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

RAD1, Q9VQD4

Locations in the PathwayBrowser

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DNA Repair (Drosophila melanogaster)

- DNA Double-Strand Break Repair (Drosophila melanogaster)
  - Homology Directed Repair (Drosophila melanogaster)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Drosophila melanogaster)
      - Processing of DNA double-strand break ends (Drosophila melanogaster)
        
        ATR phosphorylates RPA2 (Drosophila melanogaster)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Rad1 [nucleoplasm] (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Rad1 [nucleoplasm] (Drosophila melanogaster)
        
        Activation of CHEK1 at resected DNA DSBs (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Rad1 [nucleoplasm] (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Rad1 [nucleoplasm] (Drosophila melanogaster)
        
        CHEK1 is recruited to resected DNA DSBs (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Rad1 [nucleoplasm] (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Rad1 [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional Regulation by TP53 (Drosophila melanogaster)
      - Regulation of TP53 Activity (Drosophila melanogaster)
        
        Regulation of TP53 Activity through Phosphorylation (Drosophila melanogaster)
        
        ATR phosphorylates TP53 (Drosophila melanogaster)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Rad1 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VQD4

Gene Names

Rad1

Reference Genes

BioGPS Gene:33440 Rad1

ENSEMBL:FBgn0026778

Flybase:FBgn0026778

KEGG Gene (Drosophila melanogaster):Dmel_CG3240 Rad1

Monarch:33440 Rad1

NCBI Gene:33440 Rad1

UCSC:Q9VQD4 Rad1

Reference Transcript

RefSeq:NM_058092.4 Rad1

Other Identifiers

144159_at

1624375_at

1632949_at

33440

GO:0000077

GO:0000228

GO:0003824

GO:0005634

GO:0005694

GO:0006281

GO:0006974

GO:0008408

GO:0016787

GO:0023052

GO:0030896

GO:0043226

Participates

as a component of

RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)

Inferred From

RAD1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_477440.1

Flybase

FBgn0026778

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q95RA8 mats	4	MATS [cytosol] (R-DME-390158) Phospho MATS [cytosol] (R-DME-390125) phospho-p-T12,T35-MOB1A [cytosol] (R-DME-2028628) MOB1A [cytosol] (R-DME-2028568)	0.488	2

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