Reactome | phospho-p-S32,S36-NFKBIA [cytosol]

phospho-p-S32,S36-NFKBIA [cytosol]

Stable Identifier

R-DME-177677

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

Q03017

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q03017 cact

Gene Names

cact, CG5848

Chain

chain:1-500

Reference Genes

BioGPS Gene:34969 cact

dbSNP Gene:34969 cact

KEGG Gene (Drosophila melanogaster):Dmel_CG5848 cact

Monarch:34969 cact

NCBI Gene:34969 cact

UCSC:Q03017 cact

Reference Transcript

Other Identifiers

153684_at

1636926_s_at

7227.FBpp0080402

AAA28407.1

AAA28408.1

AAN10936.1

AAN10937.1

AAS64714.1

AGB93031.1

AY069399

EntrezGene:34969

FBgn0000250

FBpp0080402

FBpp0080403

FBpp0089296

FBpp0308004

FBtr0080844

FBtr0080845

FBtr0080847

FBtr0337081

GO:0000003

GO:0002376

GO:0002789

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0006950

GO:0006952

GO:0006967

GO:0007165

GO:0007253

GO:0007275

GO:0007399

GO:0008063

GO:0008134

GO:0008150

GO:0009058

GO:0009620

GO:0009950

GO:0009953

GO:0019730

GO:0019732

GO:0022607

GO:0030097

GO:0030154

GO:0031594

GO:0034641

GO:0045087

GO:0045611

GO:0045751

GO:0046843

GO:0048477

GO:0048646

GO:0048856

GO:0051059

IPR002110

IPR020683

IPR036770

L04964

M9PD95

NM_001273567.1

NM_057594.4

NM_057595.4

NM_165152.2

NM_205999.2

NP_001260496.1

NP_476942.1

NP_476943.1

NP_723960.1

NP_995721.1

PF12796

PF13637

PR01415

Q03017-1

SM00248

UPI0000000F85

Participant Of

hasComponent

input

IkB is ubiquitinated and degraded

hasMember

p-IKB alpha,beta,epsilon [cytosol]

Other forms of this molecule

CACT [cytosol]

Phospho CACT [cytosol]

PolyUb-NFKBIA [cytosol]

NFKBIA [nucleoplasm]

phospho-K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol]

phospho-Ub-21,22-p-S32,S36-NFKBIA [cytosol]

NFKBIA [cytosol]

Inferred From

p-S32,S36-NFKBIA [cytosol] (Homo sapiens)

Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 32 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 36 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_476943.1, NP_995721.1, NP_001260496.1, NP_476942.1, NP_723960.1

Flybase

FBgn0000250

PRO

Q03017

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15330 dl	23	Phospho DL [cytosol] (R-DME-214732) DL [cytosol] (R-DME-206011) Phospho DL [nucleoplasm] (R-DME-214731) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-DME-4755466) MeK310-RELA [nucleoplasm] (R-DME-8865233) phospho-p-S276,5xAcK-RELA [nucleoplasm] (R-DME-5660642) NFKB1(1-968) [cytosol] (R-DME-451607) NFKB2(1-454) [cytosol] (R-DME-168144) NFKB1(1-433) [cytosol] (R-DME-168168) RELA [cytosol] (R-DME-168172) NFKB1(1-433) [nucleoplasm] (R-DME-177655) NFKB2(1-454) [nucleoplasm] (R-DME-177674) RELA [nucleoplasm] (R-DME-177676) REL [cytosol] (R-DME-1168579) REL [nucleoplasm] (R-DME-1168585) RELB [cytosol] (R-DME-5607652) phospho-K48-polyUb-p-7S-p100 [cytosol] (R-DME-5607636) NFKB1(1-968) [specific granule lumen] (R-DME-6799557) NFKB1(1-968) [extracellular region] (R-DME-6806304) NFKB1(1-968) [secretory granule lumen] (R-DME-6801004) phospho-p-S276-RELA [nucleoplasm] (R-DME-5624468) RELB [nucleoplasm] (R-DME-5607656) NFKB2(1-900) [cytosol] (R-DME-2677931)	0.61	5
UniProt:Q9V393 krz	8	ARRB1 [Golgi membrane] (R-DME-350831-3) ARRB1 [cytoplasmic vesicle membrane] (R-DME-351187-3) ARRB1 [lysosomal membrane] (R-DME-432701-3) PolyUb-ARRB2 [cytosol] (R-DME-6783000) PolyUb-ARRB1 [cytosol] (R-DME-6783186-3) Krz [cytosol] (R-DME-2071841) ARRB2 [cytosol] (R-DME-416464) ARRB1 [cytosol] (R-DME-264470-3)	0.544	2
UniProt:Q9VEZ5 IKKbeta	4	Phospho IRD5 [cytosol] (R-DME-206139) IRD5 [cytosol] (R-DME-206001) phospho-Q9VEZ5 [cytosol] (R-DME-9008705-2) TBK1 [cytosol] (R-DME-166267-2)	0.544	2