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phospho-p-S32,S36-NFKBIA [cytosol]
Stable Identifier
R-DME-177677
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
Q03017
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
phospho-p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
phospho-p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
phospho-p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
phospho-p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
phospho-p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Death Receptor Signalling (Drosophila melanogaster)
p75 NTR receptor-mediated signalling (Drosophila melanogaster)
p75NTR signals via NF-kB (Drosophila melanogaster)
NF-kB is activated and signals survival (Drosophila melanogaster)
IkB is ubiquitinated and degraded (Drosophila melanogaster)
Ubiquitinated phospho-IkB [cytosol] (Drosophila melanogaster)
phospho-p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
phospho-p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q03017 cact
Gene Names
cact, CG5848
Chain
chain:1-500
Reference Genes
BioGPS Gene:34969 cact
dbSNP Gene:34969 cact
KEGG Gene (Drosophila melanogaster):Dmel_CG5848 cact
Monarch:34969 cact
NCBI Gene:34969 cact
UCSC:Q03017 cact
Reference Transcript
RefSeq:NM_165152.2 cact
RefSeq:NM_057594.4 cact
RefSeq:NM_001273567.1 cact
RefSeq:NM_057595.4 cact
RefSeq:NM_205999.2 cact
Other Identifiers
153684_at
1636926_s_at
7227.FBpp0080402
AAA28407.1
AAA28408.1
AAN10936.1
AAN10937.1
AAS64714.1
AGB93031.1
AY069399
EntrezGene:34969
FBgn0000250
FBpp0080402
FBpp0080403
FBpp0089296
FBpp0308004
FBtr0080844
FBtr0080845
FBtr0080847
FBtr0337081
GO:0000003
GO:0002376
GO:0002789
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0006950
GO:0006952
GO:0006967
GO:0007165
GO:0007253
GO:0007275
GO:0007399
GO:0008063
GO:0008134
GO:0008150
GO:0009058
GO:0009620
GO:0009950
GO:0009953
GO:0019730
GO:0019732
GO:0022607
GO:0030097
GO:0030154
GO:0031594
GO:0034641
GO:0045087
GO:0045611
GO:0045751
GO:0046843
GO:0048477
GO:0048646
GO:0048856
GO:0051059
IPR002110
IPR020683
IPR036770
L04964
M9PD95
NM_001273567.1
NM_057594.4
NM_057595.4
NM_165152.2
NM_205999.2
NP_001260496.1
NP_476942.1
NP_476943.1
NP_723960.1
NP_995721.1
PF12796
PF13637
PR01415
Q03017-1
SM00248
UPI0000000F85
Participant Of
hasComponent
NF-KappaB p50:p50:p-IKBA [cytosol]
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol]
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol]
p-S32,36-IkB-alpha:NF-kB complex [cytosol]
Ubiquitinated phospho-IkB [cytosol]
input
IkB is ubiquitinated and degraded
hasMember
p-IKB alpha,beta,epsilon [cytosol]
Other forms of this molecule
CACT [cytosol]
Phospho CACT [cytosol]
PolyUb-NFKBIA [cytosol]
NFKBIA [nucleoplasm]
phospho-K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol]
phospho-Ub-21,22-p-S32,S36-NFKBIA [cytosol]
NFKBIA [cytosol]
Inferred From
p-S32,S36-NFKBIA [cytosol] (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 32 (in Homo sapiens)
Coordinate
32
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 36 (in Homo sapiens)
Coordinate
36
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_476943.1
,
NP_995721.1
,
NP_001260496.1
,
NP_476942.1
,
NP_723960.1
Flybase
FBgn0000250
PRO
Q03017
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15330 dl
23
Phospho DL [cytosol]
(R-DME-214732)
DL [cytosol]
(R-DME-206011)
Phospho DL [nucleoplasm]
(R-DME-214731)
SUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-DME-4755466)
MeK310-RELA [nucleoplasm]
(R-DME-8865233)
phospho-p-S276,5xAcK-RELA [nucleoplasm]
(R-DME-5660642)
NFKB1(1-968) [cytosol]
(R-DME-451607)
NFKB2(1-454) [cytosol]
(R-DME-168144)
NFKB1(1-433) [cytosol]
(R-DME-168168)
RELA [cytosol]
(R-DME-168172)
NFKB1(1-433) [nucleoplasm]
(R-DME-177655)
NFKB2(1-454) [nucleoplasm]
(R-DME-177674)
RELA [nucleoplasm]
(R-DME-177676)
REL [cytosol]
(R-DME-1168579)
REL [nucleoplasm]
(R-DME-1168585)
RELB [cytosol]
(R-DME-5607652)
phospho-K48-polyUb-p-7S-p100 [cytosol]
(R-DME-5607636)
NFKB1(1-968) [specific granule lumen]
(R-DME-6799557)
NFKB1(1-968) [extracellular region]
(R-DME-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-DME-6801004)
phospho-p-S276-RELA [nucleoplasm]
(R-DME-5624468)
RELB [nucleoplasm]
(R-DME-5607656)
NFKB2(1-900) [cytosol]
(R-DME-2677931)
0.61
5
UniProt:Q9V393 krz
8
ARRB1 [Golgi membrane]
(R-DME-350831-3)
ARRB1 [cytoplasmic vesicle membrane]
(R-DME-351187-3)
ARRB1 [lysosomal membrane]
(R-DME-432701-3)
PolyUb-ARRB2 [cytosol]
(R-DME-6783000)
PolyUb-ARRB1 [cytosol]
(R-DME-6783186-3)
Krz [cytosol]
(R-DME-2071841)
ARRB2 [cytosol]
(R-DME-416464)
ARRB1 [cytosol]
(R-DME-264470-3)
0.544
2
UniProt:Q9VEZ5 IKKbeta
4
Phospho IRD5 [cytosol]
(R-DME-206139)
IRD5 [cytosol]
(R-DME-206001)
phospho-Q9VEZ5 [cytosol]
(R-DME-9008705-2)
TBK1 [cytosol]
(R-DME-166267-2)
0.544
2
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