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phospho-cact [cytosol]
Stable Identifier
R-DME-177677
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
p-S32,S36-NFKBIA, Q03017
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Downstream signaling events of B Cell Receptor (BCR) (Drosophila melanogaster)
Activation of NF-kappaB in B cells (Drosophila melanogaster)
Activated IKK phosphorylates I-kappaB (Drosophila melanogaster)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Drosophila melanogaster)
NF-KappaB p50:p50:p-IKBA [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Drosophila melanogaster)
p-IKB alpha,beta,epsilon [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
NF-kappaB p50:p65:p-IKB [cytosol] (Drosophila melanogaster)
p-IKB alpha,beta,epsilon [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
NF-kappaB p65:p65:p-IKB [cytosol] (Drosophila melanogaster)
p-IKB alpha,beta,epsilon [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
IKBA is phosphorylated by Phospho IKKB kinase (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Cytosolic sensors of pathogen-associated DNA (Drosophila melanogaster)
ZBP1(DAI) mediated induction of type I IFNs (Drosophila melanogaster)
RIP-mediated NFkB activation via ZBP1 (Drosophila melanogaster)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Drosophila melanogaster)
TRAF6 mediated NF-kB activation (Drosophila melanogaster)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated NF-kB activation (Drosophila melanogaster)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Death Receptor Signaling (Drosophila melanogaster)
p75 NTR receptor-mediated signalling (Drosophila melanogaster)
p75NTR signals via NF-kB (Drosophila melanogaster)
NF-kB is activated and signals survival (Drosophila melanogaster)
IkB is ubiquitinated and degraded (Drosophila melanogaster)
Ubiquitinated phospho-IkB [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q03017 cact
Gene Names
cact, CG5848
Chain
chain:1-500
Reference Genes
BioGPS Gene:34969 cact
CTD Gene:34969 cact
KEGG:dme:Dmel_CG5848 cact
Monarch:34969 cact
NCBI Gene:34969 cact
UCSC:Q03017 cact
Reference Transcript
RefSeq:NM_057595.4 cact
RefSeq:NM_057594.4 cact
RefSeq:NM_001273567.1 cact
RefSeq:NM_165152.2 cact
RefSeq:NM_205999.2 cact
Other Identifiers
153684_at
1629899_at
1636926_s_at
34969
GO:0002376
GO:0002789
GO:0005515
GO:0005737
GO:0005829
GO:0006355
GO:0007253
GO:0007399
GO:0009950
GO:0009953
GO:0019730
GO:0022414
GO:0031594
GO:0043124
GO:0043226
GO:0045611
GO:0045751
GO:0046843
GO:0048477
GO:0048856
GO:0051059
GO:0051220
GO:0071212
GO:0071356
GO:0098542
GO:0140311
GO:0140313
Participates
as a component of
NF-KappaB p50:p50:p-IKBA [cytosol] (Drosophila melanogaster)
Ubiquitinated phospho-IkB [cytosol] (Drosophila melanogaster)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Drosophila melanogaster)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
as a member of
p-IKB alpha,beta,epsilon [cytosol] (Drosophila melanogaster)
as an input of
IkB is ubiquitinated and degraded (Drosophila melanogaster)
as an output of
IKBA is phosphorylated by Phospho IKKB kinase (Drosophila melanogaster)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
Other forms of this molecule
CACT [cytosol]
Phospho CACT [cytosol]
cact [nucleoplasm]
phospho-cact [cytosol]
cact [cytosol]
Inferred From
Phospho-NF-kappaB Inhibitor [cytosol]
(Homo sapiens)
p-S32,S36-NFKBIA [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 32 (in Homo sapiens)
Coordinate
32
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 36 (in Homo sapiens)
Coordinate
36
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001260496.1
,
NP_476943.1
,
NP_476942.1
,
NP_995721.1
,
NP_723960.1
ENSEMBL
FBpp0080402
,
FBpp0080403
,
FBpp0089296
,
FBpp0308004
,
FBtr0080847
,
FBtr0337081
,
FBtr0080844
,
FBtr0080845
FlyBase
FBgn0000250
PRO
Q03017
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15330 dl
14
dl [nucleoplasm]
(R-DME-177676)
dl [cytosol]
(R-DME-168172)
dl [cytosol]
(R-DME-5607652)
dl [nucleoplasm]
(R-DME-5607656)
phospho-dl [nucleoplasm]
(R-DME-5624468)
phospho-dl [nucleoplasm]
(R-DME-5660642)
dl [cytosol]
(R-DME-1168579)
dl [nucleoplasm]
(R-DME-1168585)
dl [nucleoplasm]
(R-DME-4755466)
phospho-dl [nucleoplasm]
(R-DME-9861499)
dl [nucleoplasm]
(R-DME-8865233)
Phospho DL [nucleoplasm]
(R-DME-214731)
Phospho DL [cytosol]
(R-DME-214732)
DL [cytosol]
(R-DME-206011)
0.745
7
UniProt:Q9VR99
1
cactin [nucleoplasm]
(R-DME-9769591)
0.581
5
UniProt:Q9VEZ5 IKKbeta
8
IRD5 [cytosol]
(R-DME-206001)
Phospho IRD5 [cytosol]
(R-DME-206139)
phospho-p-Y187,Y198-CHUK [cytosol]
(R-DME-9861501)
phospho-p-T23-CHUK [cytosol]
(R-DME-198615)
phospho-p-S176,S180-CHUK [cytosol]
(R-DME-177667)
phospho-p-S177,S181-IKBKB [cytosol]
(R-DME-202506)
CHUK [cytosol]
(R-DME-168104)
IKBKB [cytosol]
(R-DME-168114)
0.544
2
UniProt:Q9V393 krz
10
krz [cytoplasmic vesicle membrane]
(R-DME-351187-3)
krz [Golgi membrane]
(R-DME-350831-3)
krz [lysosomal membrane]
(R-DME-432701-3)
krz [endocytic vesicle membrane]
(R-DME-9910881)
krz [endocytic vesicle membrane]
(R-DME-9910882-3)
krz [cytosol]
(R-DME-6783000)
krz [cytosol]
(R-DME-6783186-3)
Krz [cytosol]
(R-DME-2071841)
krz [cytosol]
(R-DME-416464)
krz [cytosol]
(R-DME-264470-3)
0.544
2
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