Reactome | TUBB1 [cytosol]

TUBB1 [cytosol]

Stable Identifier

R-DME-191703

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

P61857

Locations in the PathwayBrowser

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Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Drosophila melanogaster)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Drosophila melanogaster)
      - Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)

Hemostasis (Drosophila melanogaster)

- Factors involved in megakaryocyte development and platelet production (Drosophila melanogaster)
  - Kinesins (Drosophila melanogaster)
    - Kinesins move along microtubules consuming ATP (Drosophila melanogaster)
      - Kinesins:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)

Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - Asparagine N-linked glycosylation (Drosophila melanogaster)
    - Transport to the Golgi and subsequent modification (Drosophila melanogaster)
      - ER to Golgi Anterograde Transport (Drosophila melanogaster)
        
        COPI-mediated anterograde transport (Drosophila melanogaster)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)

Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - ER to Golgi Anterograde Transport (Drosophila melanogaster)
    - COPI-mediated anterograde transport (Drosophila melanogaster)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Drosophila melanogaster)
    - Golgi-to-ER retrograde transport (Drosophila melanogaster)
      - COPI-dependent Golgi-to-ER retrograde traffic (Drosophila melanogaster)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Drosophila melanogaster)
        
        Kinesins:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Drosophila melanogaster)
        
        Kinesins:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)
      - COPI-independent Golgi-to-ER retrograde traffic (Drosophila melanogaster)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule [cytosol] (Drosophila melanogaster)
        
        Microtubule protofilament [cytosol] (Drosophila melanogaster)
        
        alpha-beta tubulin dimer [cytosol] (Drosophila melanogaster)
        
        beta-tubulin:GDP [cytosol] (Drosophila melanogaster)
        
        beta-tubulin [cytosol] (Drosophila melanogaster)
        
        Homologues of TUBB1 [cytosol] (Drosophila melanogaster)
        
        TUBB1 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P61857

Reference Genes

BioGPS Gene:41124

CTD Gene:41124

ENSEMBL:FBgn0003889

Flybase:FBgn0003889

KEGG Gene (Drosophila melanogaster):Dmel_CG9359

Monarch:41124

NCBI Gene:41124

Reference Transcript

RefSeq:NM_079566.4

Other Identifiers

143393_at

1624746_at

41124

GO:0000166

GO:0000226

GO:0000278

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005525

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0007435

GO:0016787

GO:0043226

GO:0046872

GO:0048856

Participates

as a member of

Homologues of TUBB1 [cytosol] (Drosophila melanogaster)

Other forms of this molecule

TUBB8 [cytosol]

TUBB2A [cytosol]

Inferred From

TUBB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_524290.2

Flybase

FBgn0003889

PRO

P61857

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9W385	1	fh [mitochondrial matrix] (R-DME-1362390)	0.488	2

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