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Axn [cytosol]
Stable Identifier
R-DME-195249
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
AXIN1, Q9V407
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
Degradation of beta-catenin by the destruction complex (Drosophila melanogaster)
AXIN is phosphorylated in the destruction complex (Drosophila melanogaster)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Axn [cytosol] (Drosophila melanogaster)
TCF dependent signaling in response to WNT (Drosophila melanogaster)
Degradation of AXIN (Drosophila melanogaster)
AXIN is ubiquitinated by SMURF2 (Drosophila melanogaster)
AXIN:SMURF2 [cytosol] (Drosophila melanogaster)
Axn [cytosol] (Drosophila melanogaster)
SMURF2 binds AXIN (Drosophila melanogaster)
AXIN:SMURF2 [cytosol] (Drosophila melanogaster)
Axn [cytosol] (Drosophila melanogaster)
Axn [cytosol] (Drosophila melanogaster)
Tankyrase ADP-ribosylates AXIN (Drosophila melanogaster)
AXIN:TNKS [cytosol] (Drosophila melanogaster)
Axn [cytosol] (Drosophila melanogaster)
Tankyrase binds AXIN (Drosophila melanogaster)
AXIN:TNKS [cytosol] (Drosophila melanogaster)
Axn [cytosol] (Drosophila melanogaster)
Axn [cytosol] (Drosophila melanogaster)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Drosophila melanogaster)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Drosophila melanogaster)
GSK3B:AXIN1 [cytosol] (Drosophila melanogaster)
Axn [cytosol] (Drosophila melanogaster)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Drosophila melanogaster)
GSK3B:AXIN1 [cytosol] (Drosophila melanogaster)
Axn [cytosol] (Drosophila melanogaster)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Drosophila melanogaster)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Drosophila melanogaster)
GSK3B:AXIN1 [cytosol] (Drosophila melanogaster)
Axn [cytosol] (Drosophila melanogaster)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Drosophila melanogaster)
GSK3B:AXIN1 [cytosol] (Drosophila melanogaster)
Axn [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9V407 Axn
Gene Names
Axn, CG7926
Chain
chain:1-745
Reference Genes
BioGPS Gene:43565 Axn
CTD Gene:43565 Axn
KEGG Gene (Drosophila melanogaster):Dmel_CG7926 Axn
Monarch:43565 Axn
NCBI Gene:43565 Axn
UCSC:Q9V407 Axn
Reference Transcript
RefSeq:NM_170457.3 Axn
RefSeq:NM_170458.2 Axn
Other Identifiers
43565
GO:0000003
GO:0003674
GO:0005102
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006950
GO:0007165
GO:0007267
GO:0007275
GO:0007367
GO:0007450
GO:0007455
GO:0007507
GO:0007623
GO:0008013
GO:0008150
GO:0008219
GO:0008587
GO:0009056
GO:0009790
GO:0010941
GO:0016055
GO:0019899
GO:0019901
GO:0030154
GO:0030707
GO:0030877
GO:0032436
GO:0032991
GO:0035019
GO:0035293
GO:0042594
GO:0043226
GO:0048477
GO:0048856
GO:0060090
GO:0090090
Participates
as an input of
SMURF2 binds AXIN (Drosophila melanogaster)
Tankyrase binds AXIN (Drosophila melanogaster)
as a component of
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
AXIN:SMURF2 [cytosol] (Drosophila melanogaster)
AXIN:TNKS [cytosol] (Drosophila melanogaster)
GSK3B:AXIN1 [cytosol] (Drosophila melanogaster)
Other forms of this molecule
AXN [cytosol]
Phospho AXN [cytosol]
Phospho (3 sites) AXN [cytosol]
Axn [cytosol]
Axn [cytosol]
phospho-Axn [cytosol]
phospho-Axn [cytosol]
phospho-Axn [cytosol]
phospho-Axn [cytosol]
Axn [cytosol]
phospho-Axn [cytosol]
Inferred From
AXIN1 [cytosol]
(Homo sapiens)
AXIN [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_733336.1
,
NP_733337.1
Flybase
FBgn0026597
PRO
Q9V407
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18824 arm
20
arm [cytosol]
(R-DME-448839)
arm [nucleoplasm]
(R-DME-3451168)
arm [cytosol]
(R-DME-202930)
arm [cytosol]
(R-DME-202950)
phospho-arm [cytosol]
(R-DME-8942374)
phospho-arm [cytosol]
(R-DME-8942369)
phospho-arm [cytosol]
(R-DME-8942367)
phospho-arm [cytosol]
(R-DME-8942363)
arm [plasma membrane]
(R-DME-9038440)
arm [plasma membrane]
(R-DME-437260)
arm [ficolin-1-rich granule lumen]
(R-DME-6801028)
arm [extracellular region]
(R-DME-6806309)
arm [specific granule lumen]
(R-DME-6799534)
phospho-arm [cytosol]
(R-DME-3134933)
phospho-arm [nucleoplasm]
(R-DME-3134926)
arm [cytosol]
(R-DME-201598)
Phospho (4 sites) ARM [cytosol]
(R-DME-205960)
ARM [cytosol]
(R-DME-205774)
Phospho ARM [cytosol]
(R-DME-206159)
ARM [nucleoplasm]
(R-DME-205878)
0.508
2
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