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sl [cytosol]
Stable Identifier
R-DME-202320
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
PLCG1, Q9VXH3
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
TCR signaling (Drosophila melanogaster)
Generation of second messenger molecules (Drosophila melanogaster)
Phosphorylation of PLC-gamma1 (Drosophila melanogaster)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Interferon Signaling (Drosophila melanogaster)
Antiviral mechanism by IFN-stimulated genes (Drosophila melanogaster)
ISG15 antiviral mechanism (Drosophila melanogaster)
ISGylation of host proteins (Drosophila melanogaster)
ISG15 targets [cytosol] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
ISGylated host proteins [cytosol] (Drosophila melanogaster)
ISG15 targets [cytosol] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Drosophila melanogaster)
ISG15 targets [cytosol] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
ISGylated host proteins [cytosol] (Drosophila melanogaster)
ISG15 targets [cytosol] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
DAP12 interactions (Drosophila melanogaster)
DAP12 signaling (Drosophila melanogaster)
Activation of RAC1 by VAV2/3 (Drosophila melanogaster)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Autophosphorylation of BTK/ITK (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
FCERI mediated MAPK activation (Drosophila melanogaster)
Activation of RAC1 by VAV (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Autophosphorylation of PAK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Phosphorylation and activation of VAV (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
EGFR interacts with phospholipase C-gamma (Drosophila melanogaster)
EGFR activates PLC-gamma1 by phosphorylation (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
Phospholipase C-gamma1 binds to the activated EGF receptor (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
sl [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VXH3
Gene Names
sl
Reference Genes
BioGPS Gene:32601 sl
CTD Gene:32601 sl
ENSEMBL:FBgn0003416
Flybase:FBgn0003416
KEGG Gene (Drosophila melanogaster):Dmel_CG4200 sl
Monarch:32601 sl
NCBI Gene:32601 sl
UCSC:Q9VXH3 sl
Reference Transcript
RefSeq:NM_057378.3 sl
Other Identifiers
153466_at
1628815_at
32601
GO:0002009
GO:0002376
GO:0003824
GO:0004435
GO:0005515
GO:0006629
GO:0007165
GO:0007298
GO:0008081
GO:0009395
GO:0009887
GO:0010634
GO:0016042
GO:0016787
GO:0022414
GO:0023052
GO:0030154
GO:0030307
GO:0032868
GO:0035556
GO:0042059
GO:0042690
GO:0045596
GO:0045677
GO:0045873
GO:0048015
GO:0048468
GO:0048513
GO:0048856
GO:0048870
GO:0051209
GO:0055065
GO:0055085
GO:0060429
GO:0070373
GO:0110165
Participates
as a member of
ISG15 targets [cytosol] (Drosophila melanogaster)
as an input of
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
Phospholipase C-gamma1 binds to the activated EGF receptor (Drosophila melanogaster)
as a component of
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Drosophila melanogaster)
Other forms of this molecule
phospho-sl [cytosol]
phospho-sl [plasma membrane]
phospho-sl [plasma membrane]
phospho-sl [cytosol]
sl [cytosol]
phospho-sl [plasma membrane]
sl [plasma membrane]
phospho-sl [plasma membrane]
sl [plasma membrane]
phospho-sl [plasma membrane]
Inferred From
PLC gamma1,2 [cytosol]
(Homo sapiens)
PLCG1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_476726.2
Flybase
FBgn0003416
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