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PP2A-29B [cytosol]
Stable Identifier
R-DME-205936
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Circadian Clock pathway (Drosophila melanogaster)
Dephosphorylation of PER (Drosophila melanogaster)
Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phosphorylation of PER and TIM (Drosophila melanogaster)
CRY is phosphorylated by SGG (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
PER is phosphorylated by DCO (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phosphorylated PER is phosphorylated by CK2 (Drosophila melanogaster)
RAS85D:GTP:SRC42A:Phospho CNK:14-3-3epsilon dimer:Phospho PHL:Phospho KSR:14-3-3epsilon dimer:AVE:DSOR1:CK2:PAR-1:PP2A [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
TIM is phosphorylated by CK2 (Drosophila melanogaster)
RAS85D:GTP:SRC42A:Phospho CNK:14-3-3epsilon dimer:Phospho PHL:Phospho KSR:14-3-3epsilon dimer:AVE:DSOR1:CK2:PAR-1:PP2A [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Hedgehog pathway (Drosophila melanogaster)
N-HH ligand bound to PTC receptor complex (Drosophila melanogaster)
Activation of SMO (Drosophila melanogaster)
Phosphorylation of SMO (Drosophila melanogaster)
Phosphorylation of SMO by CKIalpha (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phosphorylation of SMO by PKA-C1 (Drosophila melanogaster)
CNK:PHL:Phospho (2 sites) KSR:AVE:DSOR1:CK2:PAR-1:PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
N-HH ligand not bound to PTC receptor complex (Drosophila melanogaster)
Assembly of the CI containing complexes (Drosophila melanogaster)
Phosphorylation of CI (Drosophila melanogaster)
Phosphorylation of CI by PKA-C1 (Drosophila melanogaster)
CNK:PHL:Phospho (2 sites) KSR:AVE:DSOR1:CK2:PAR-1:PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phosphorylation of CI by SGG (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Ubiquitination and proteolysis of phosphorylated CI (Drosophila melanogaster)
SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Wingless pathway (Drosophila melanogaster)
WG ligand bound to FZ receptors (Drosophila melanogaster)
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM (Drosophila melanogaster)
Destabilisation and degradation of AXN in the 'destruction complex' (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
WG ligand not bound to FZ receptors (Drosophila melanogaster)
Assembly of the 'destruction complex' (Drosophila melanogaster)
ARM binds to APC and AXN in the 'destruction complex' (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Formation of the 'destruction complex' (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phosphorylation of ARM (Drosophila melanogaster)
Further phosphorylation of ARM by SGG (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phospho ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phosphorylation of ARM by CKIalpha (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phospho ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC (Drosophila melanogaster)
Further phosphorylation of APC by DCO (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (2 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Further phosphorylation of APC by SGG (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC by DCO (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC by SGG (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (2 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
Ubiquitination and degradation of phosphorylated ARM (Drosophila melanogaster)
Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
SLMB binds to phosphorylated ARM to form the 'destruction complex' (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P36179 Pp2A-29B
Gene Names
Pp2A-29B, CG17291
Chain
initiator methionine:, chain:2-591
Reference Genes
BioGPS Gene:2768940 Pp2A-29B
KEGG Gene (Drosophila melanogaster):Dmel_CG17291 Pp2A-29B
Monarch:2768940 Pp2A-29B
NCBI Gene:2768940 Pp2A-29B
Reference Transcript
RefSeq:NM_001032056.3 Pp2A-29B
RefSeq:NM_001032054.3 Pp2A-29B
RefSeq:NM_001032055.3 Pp2A-29B
Other Identifiers
153686_at
1625851_s_at
2768940
GO:0000159
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005814
GO:0005815
GO:0005829
GO:0005856
GO:0006470
GO:0006914
GO:0007010
GO:0007059
GO:0007098
GO:0007099
GO:0007168
GO:0019888
GO:0023052
GO:0035331
GO:0036211
GO:0043226
GO:0045752
GO:0045879
GO:0046627
GO:0051225
GO:0090443
GO:0098772
Participates
as a component of
PP2A [cytosol] (Drosophila melanogaster)
PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
Other forms of this molecule
PP2A-29B [nucleoplasm]
Pp2A-29B [nucleoplasm]
Pp2A-29B [nucleoplasm]
Pp2A-29B [cytosol]
Pp2A-29B [cytosol]
Cross References
RefSeq
NP_001027227.1
,
NP_001027225.1
,
NP_001027226.1
Flybase
FBgn0260439
PRO
P36179
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9V3I5
2
RPS6KA5 [nucleoplasm]
(R-DME-198657)
phospho-p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]
(R-DME-198683)
0.462
2
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