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TUB [cytosol]
Stable Identifier
R-DME-206155
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Toll pathway (Drosophila melanogaster)
Degradation of NF-kappa-B inhibitor, CACT (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' (Drosophila melanogaster)
DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:DL/DIF dimer:CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' (Drosophila melanogaster)
CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:Phospho DL dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:DL/DIF dimer:CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:Phospho DL/DIF dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' (Drosophila melanogaster)
Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:Phospho DL dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:Phospho DL/DIF dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
Formation of the trans-membrane 'signalling complex' (Drosophila melanogaster)
Adaptor protein complex binds to TL receptor at the plasma membrane (Drosophila melanogaster)
MYD88:TUB binds to TL receptor (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
WEK and MYD88:TUB bind to the TL receptor (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:WEK dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
MYD88 binds to TUB (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
PLL kinase binds to TUB in the TL receptor 'signalling complex' (Drosophila melanogaster)
PLL kinase binds to TL:MYD88:TUB 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:WEK dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
TUB [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P22812 tub
Gene Names
tub, tube, CG10520
Chain
chain:1-462
Reference Genes
BioGPS Gene:40554 tub
KEGG Gene (Drosophila melanogaster):Dmel_CG10520 tub
Monarch:40554 tub
NCBI Gene:40554 tub
UCSC:P22812 tub
Reference Transcript
RefSeq:NM_001202235.2 tub
Other Identifiers
153870_at
1637314_at
40554
GO:0002376
GO:0002804
GO:0003824
GO:0004674
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006915
GO:0007165
GO:0007526
GO:0008063
GO:0009605
GO:0009620
GO:0009898
GO:0009953
GO:0012501
GO:0016020
GO:0016740
GO:0019221
GO:0019904
GO:0023052
GO:0035172
GO:0043226
GO:0045087
GO:0048262
GO:0048856
GO:0098542
GO:0140096
GO:1990782
Participates
as a component of
MYD88:TUB [cytosol] (Drosophila melanogaster)
as an input of
MYD88 binds to TUB (Drosophila melanogaster)
Cross References
RefSeq
NP_001189164.1
Flybase
FBgn0003882
PRO
P22812
PDB
1D2Z
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q05652 pll
11
Phospho PLL [cytosol]
(R-DME-206109)
PLL [cytosol]
(R-DME-206070)
phospho-K63polyUb-hp-IRAK1 [endosome membrane]
(R-DME-975112)
phospho-K63polyUb-hp-IRAK1 [cytosol]
(R-DME-451565)
phospho-p-IRAK2 [endosome membrane]
(R-DME-975187)
phospho-p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-DME-975157)
phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-DME-937011)
phospho-p-IRAK2 [plasma membrane]
(R-DME-936949)
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-DME-446682)
phospho-p-IRAK2 [cytosol]
(R-DME-446636)
IRAK4 [cytosol]
(R-DME-166081)
0.927
12
UniProt:P15330 dl
13
dl [nucleoplasm]
(R-DME-177676)
dl [cytosol]
(R-DME-168172)
dl [cytosol]
(R-DME-5607652)
dl [cytosol]
(R-DME-1168579)
dl [nucleoplasm]
(R-DME-1168585)
phospho-dl [nucleoplasm]
(R-DME-5624468)
dl [nucleoplasm]
(R-DME-5607656)
phospho-dl [nucleoplasm]
(R-DME-5660642)
dl [nucleoplasm]
(R-DME-4755466)
dl [nucleoplasm]
(R-DME-8865233)
Phospho DL [nucleoplasm]
(R-DME-214731)
Phospho DL [cytosol]
(R-DME-214732)
DL [cytosol]
(R-DME-206011)
0.61
4
UniProt:Q7K105 Myd88
2
MYD88 [cytosol]
(R-DME-206015)
Myd88 [cytosol]
(R-DME-166059)
0.534
2
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