Phosphorylation of AXN and APC by SGG

Stable Identifier
R-DME-209049
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of AXN and APC by SGG
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Additional phosphorylation of the scaffolding molecules, Axin (AXN) and APC (APC/APC2), is carried out by the GSK3beta kinase orthologue Shaggy (SGG) with Ser1501 (also a priming phosphorylation) in Human APC and Ser614 and Thr609 in Mouse Axin (equivalent to Ser522 and Thr517 respectively in Fly and Ser524 and Thr519 in Human).
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol]

Physical Entity
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Murine Axin1 is further phosphorylated by Human GSK3beta (Mus musculus)
Human APC is further phosphorylated by Murine GSK3beta (Homo sapiens)
Authored
Williams, MG  (2006-07-26)
Reviewed
Nusse, R  (2008-01-19)
Created
Williams, MG  (2006-07-20)
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