Phosphorylation of AXN and APC by SGG

Stable Identifier
R-DME-209049
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Additional phosphorylation of the scaffolding molecules, Axin (AXN) and APC (APC/APC2), is carried out by the GSK3beta kinase orthologue Shaggy (SGG) with Ser1501 (also a priming phosphorylation) in Human APC and Ser614 and Thr609 in Mouse Axin (equivalent to Ser522 and Thr517 respectively in Fly and Ser524 and Thr519 in Human).
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol]

Inferred From
Authored
Reviewed
Created
Cite Us!