Destabilisation and degradation of AXN in the 'destruction complex'

Stable Identifier
R-DME-209075
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
plasma membrane
ReviewStatus
5/5
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Destabilisation and degradation of AXN in the 'destruction complex'
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Axin (AXN) is now destabilised and is degraded by an unknown mechanism, possibly by a similar ubiquitin-mediated proteolysis responsible for cytoplasmic Armadillo (ARM) degradation.
Literature References
PubMed ID Title Journal Year
12636921 Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity

Tolwinski, NS, Erdeniz, N, Wehrli, M, DiNardo, S, Wieschaus, E, Rives, A

Dev Cell 2003
10196136 Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

Takada, S, Ikeda, S, Kikuchi, A, Kishida, M, Yamamoto, H, Kishida, S

J Biol Chem 1999
10421629 Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

Willert, K, Nusse, R, Shibamoto, S

Genes Dev 1999
Participants
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Output
Participates
as an event of
Authored
Williams, MG  (2006-07-26)
Reviewed
Nusse, R  (2008-01-19)
Created
Williams, MG  (2006-06-28)
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