Disassembly of the destabilised 'destruction complex'

Stable Identifier
R-DME-209081
Type
Reaction [dissociation]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The destabilised 'destruction complex' disassembles into the cytoplasm. The cytoplasmic concentration of Axin (AXN) has now decreased.
Literature References
PubMed ID Title Journal Year
12636921 Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity

Tolwinski, NS, Erdeniz, N, Wehrli, M, DiNardo, S, Wieschaus, E, Rives, A

Dev Cell 2003
10196136 Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

Takada, S, Ikeda, S, Kikuchi, A, Kishida, M, Yamamoto, H, Kishida, S

J Biol Chem 1999
10421629 Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

Willert, K, Nusse, R, Shibamoto, S

Genes Dev 1999
Participants
Participates
Authored
Reviewed
Created
Cite Us!