ARM binds to APC and AXN in the 'destruction complex'

Stable Identifier
R-DME-209097
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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ARM binds to APC and AXN in the 'destruction complex'
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Phosphorylated APC (APC/APC2) and Axin (AXN) are able to bind cytoplasmic Armadillo (ARM) more strongly. This now brings ARM into the 'destruction complex' and within reach of the complexed kinases.
Literature References
PubMed ID Title Journal Year
10073940 Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin

Takatsu, Y, Shibuya, H, Nagai, S, Fujita, F, Ueno, N, Tomoyasu, Y, Akiyama, T, Toyoshima, K, Nakamura, M, Suzuki, A, Hamada, F

Science 1999
10457025 A Drosophila Axin homolog, Daxin, inhibits Wnt signaling

Arora, A, Willert, K, Logan, CY, Nusse, R, Fish, M

Development 1999
8990193 A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo

Levine, AJ, Hayashi, S, Polakis, P, Souza, B, Wieschaus, E, Rubinfeld, B

Proc Natl Acad Sci U S A 1997
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Authored
Williams, MG  (2006-07-26)
Reviewed
Nusse, R  (2008-01-19)
Created
Williams, MG  (2006-06-28)
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