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MYD88:TUB binds to TL receptor
Stable Identifier
R-DME-209100
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Drosophila signaling pathways (Drosophila melanogaster)
Toll pathway (Drosophila melanogaster)
Formation of the trans-membrane 'signalling complex' (Drosophila melanogaster)
Adaptor protein complex binds to TL receptor at the plasma membrane (Drosophila melanogaster)
MYD88:TUB binds to TL receptor (Drosophila melanogaster)
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Upon Spatzle (SPZ) dimer binding, leading to Toll (TL) receptor homodimerisation and activation, MYD88:TUB complex binds to the endoplasmic Toll/Interleukin-1 receptor (TIR) domain of TL receptor at the plasma membrane.
Literature References
PubMed ID
Title
Journal
Year
14685264
Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning
Wasserman, SA
,
Towb, P
,
Foster, BA
,
Sun, H
,
Chiem, DN
EMBO J
2004
Participants
Input
MYD88:TUB [cytosol]
(Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer [plasma membrane]
(Drosophila melanogaster)
Output
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB [plasma membrane]
(Drosophila melanogaster)
Participates
as an event of
Adaptor protein complex binds to TL receptor at the plasma membrane (Drosophila melanogaster)
Authored
Williams, MG (2007-07-11)
Reviewed
Lemaitre, B (2008-06-20)
Silverman, N (2008-06-20)
Created
Williams, MG (2007-07-12)
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