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SLMB binds to phosphorylated ARM to form the 'destruction complex'
Stable Identifier
R-DME-209102
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Drosophila signaling pathways (Drosophila melanogaster)
Wingless pathway (Drosophila melanogaster)
WG ligand not bound to FZ receptors (Drosophila melanogaster)
Ubiquitination and degradation of phosphorylated ARM (Drosophila melanogaster)
SLMB binds to phosphorylated ARM to form the 'destruction complex' (Drosophila melanogaster)
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The phosphorylated Armadillo (ARM) is now recognised and bound by the F-box protein Slimb (SLMB), in the E3 ubiquitin ligase assembled complex additionally containing the S-phase kinase-associated protein SKPA, the Cullin orthologue, LIN19, the Ring-box protein containg ROC1A, and the ubiquitin-conjugating enzyme orthologue EFF.
Participants
Input
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol]
(Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF [cytosol]
(Drosophila melanogaster)
Output
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol]
(Drosophila melanogaster)
Participates
as an event of
Ubiquitination and degradation of phosphorylated ARM (Drosophila melanogaster)
Authored
Williams, MG (2006-07-26)
Reviewed
Nusse, R (2008-01-19)
Created
Williams, MG (2006-06-28)
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