Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM

Stable Identifier
R-DME-209112
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM
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The binding of Dishevelled (DSH) to Axin (AXN) in the 'destruction complex' appears to inhibit the kinase Shaggy (SGG). As this component appears to be the main instigator in keeping the 'destruction complex' phosphorylated, it's inactivation means the protein phosphatase orthologue, PP2A, can dephosphorylate members of the 'destruction complex'. This results in a decreased binding affinity for Armadillo (ARM) by AXN and APC (APC/APC2). The now unphosphorylated ARM disassociates from the 'destruction complex' into the cytoplasm.
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Catalyst Activity

protein serine/threonine phosphatase activity of PP2A [cytosol]

Physical Entity
PP2A [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Inferred From
Murine Axin1 is dephosphorylated by PP2A leading to reduced binding affinity with beta-catenin (Mus musculus)
Authored
Williams, MG  (2006-07-26)
Reviewed
Nusse, R  (2008-01-19)
Created
Williams, MG  (2006-06-28)
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