Reactome | Formation of the 'destruction complex'

Formation of the 'destruction complex'

Stable Identifier

R-DME-209133

Type

Reaction [binding]

Species

Drosophila melanogaster

Compartment

cytosol

ReviewStatus

5/5

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The 'destruction complex' is formed from the large scaffolding proteins Axin (AXN) and APC (APC/APC2). This enables regulating molecules such as the kinases, CKIalpha, DCO, and Shaggy (SGG) and the phosphatase, PP2A to be held together in close proximity where they can regulate the phosphorylation of the scaffolding molecules and cytoplasmic Armadillo (ARM). The protein serine/threonine phosphatase PP2A is made up of the regulatory subunit A, PP2A-29B; the regulatory subunit B, Twins (TWS); and the catalytic subunit C, Microtubule star (MTS).

Literature References

PubMed ID	Title	Journal	Year
10073940	Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin Takatsu, Y, Shibuya, H, Nagai, S, Fujita, F, Ueno, N, Tomoyasu, Y, Akiyama, T, Toyoshima, K, Nakamura, M, Suzuki, A, Hamada, F	Science	1999
10838083	Biochemical characterization of the Drosophila axin protein Yanagawa, S, Lee, JS, Matsuda, Y, Ishimoto, A	FEBS Lett	2000
10457025	A Drosophila Axin homolog, Daxin, inhibits Wnt signaling Arora, A, Willert, K, Logan, CY, Nusse, R, Fish, M	Development	1999
8990193	A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo Levine, AJ, Hayashi, S, Polakis, P, Souza, B, Wieschaus, E, Rubinfeld, B	Proc Natl Acad Sci U S A	1997