Phosphorylation of AXN and APC by DCO

Stable Identifier
R-DME-209143
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of AXN and APC by DCO
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Axin (AXN) and APC (APC/APC2) in the 'destruction complex' are primed for phosphorylation by the CKIepsilon orthologue DCO. Ser1505 in Human APC and Ser531 in Human Axin (equivalent to Ser621 in Mouse and Ser529 in Fly) are phosphorylated.
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol]

Physical Entity
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Human APC is initially phosphorylated by Murine CKIepsilon (Homo sapiens)
Authored
Williams, MG  (2006-07-26)
Reviewed
Nusse, R  (2008-01-19)
Created
Williams, MG  (2006-06-28)
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