Reactome | CI activates transcription

CI activates transcription

Stable Identifier

R-DME-209215

Type

Reaction [transition]

Species

Drosophila melanogaster

Compartment

nucleoplasm

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Cubitus Interruptus (CI) activates transcription of ptc and several tissue-specific target genes that include direct CI binding sites in their regulatory sequences. CREB binding protein, CBP (NEJ) co-activator contributes to transcriptional activation.

Literature References

PubMed ID	Title	Journal	Year
9431812	Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer Von Ohlen, T, Hooper, JE	Mech Dev	1997
11997517	The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogaster Ludlam, WH, Taylor, MH, Tanner, KG, Denu, JM, Goodman, RH, Smolik, SM	Mol Cell Biol	2002
9109493	Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling Akimaru, H, Chen, Y, Dai, P, Hou, DX, Nonaka, M, Smolik, SM, Armstrong, S, Goodman, RH, Ishii, S	Nature	1997
10102270	Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus Methot, N, Basler, K	Cell	1999
8769644	Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins Alexandre, C, Jacinto, A, Ingham, PW	Genes Dev	1996
9122207	Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein Von Ohlen, T, Lessing, D, Nusse, R, Hooper, JE	Proc Natl Acad Sci U S A	1997
10862738	The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic gli-binding sites Müller, B, Basler, K	Development	2000