Phosphorylated DL/DIF dimer activates transcription

Stable Identifier
R-DME-209218
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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In the nucleus, phosphorylated Dorsal/Dif (DL/DIF) homodimer binds to its target genes and activates transcription.
Literature References
PubMed ID Title Journal Year
7859742 Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila

Meister, M, Lemaitre, B, Georgel, P, Steward, R, Govind, S, Reichhart, JM, Hoffmann, JA

EMBO J 1995
10843389 The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila

Ferrandon, D, Rutschmann, S, Hetru, C, Reichhart, JM, Jung, AC, Hoffmann, JA

Immunity 2000
9405661 Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

Lemaitre, B, Reichhart, JM, Hoffmann, JA

Proc Natl Acad Sci U S A 1997
8808632 The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults

Lemaitre, B, Reichhart, JM, Hoffmann, JA, Michaut, L, Nicolas, E

Cell 1996
8948598 A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo

Wasserman, SA, Karin, M, Towb, P, Allen, JL, Galindo, RL, Reach, M

Dev Biol 1996
10369678 A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF

Manfruelli, P, Lemaitre, B, Steward, R, Reichhart, JM, Hoffmann, JA

EMBO J 1999
10197979 Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor

Meng, X, Ip, YT, Khanuja, BS

Genes Dev 1999
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