Reactome | Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex'

Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex'

Stable Identifier

R-DME-209221

Type

Reaction [binding]

Species

Drosophila melanogaster

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex'

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Upon ligand binding and receptor multimerisation at the plasma membrane, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the cytoplasmic part of the receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.

Literature References

PubMed ID	Title	Journal	Year
16767093	PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan Yano, T, Kaneko, T, Silverman, N, Lim, JH, Kurata, S, Peach, C, Oshima, Y, Aggarwal, K, Goldman, WE, Ueda, K, Erturk-Hasdemir, D, Oh, BH	Nat Immunol	2006
10934188	dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD Hu, S, Yang, X	J Biol Chem	2000
12433364	The Drosophila immune defense against gram-negative infection requires the death protein dFADD Belvin, M, Georgel, P, Kappler, C, Rosse, C, Naitza, S, Reichhart, JM, Camonis, J, Gubb, D, Hoffmann, JA	Immunity	2002
15657141	Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor Lee, H, Anderson, KV, Choe, KM	Proc Natl Acad Sci U S A	2005