Reactome: A Curated Pathway Database

Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex'

Stable Identifier
R-DME-209221
Type
Reaction
Species
Drosophila melanogaster
Compartment
Locations in the PathwayBrowser
Summation

Upon ligand binding and receptor multimerisation at the plasma membrane, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the cytoplasmic part of the receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.

Literature References
Participants
Participant Of
Inferred From