DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1)

Stable Identifier
R-DME-209226
Type
Reaction
Species
Drosophila melanogaster
Compartment
Summation

The E3 ubiquitin ligases Neuralized (NEUR) or Mind Bomb 1 (MIB) ubiquitinate the Notch ligands Delta/Serrate (DL/SER).

Literature References
PubMed ID Title Journal Year
15760269 Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila

Le Borgne, R, Remaud, S, Hamel, S, Schweisguth, F

PLoS Biol 2005
16093323 The interplay between DSL proteins and ubiquitin ligases in Notch signaling

Pitsouli, C, Delidakis, C

Development 2005
11740940 Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

Lai, EC, Deblandre, GA, Kintner, C, Rubin, GM

Dev Cell 2001
15829515 The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

Lai, EC, Roegiers, F, Qin, X, Jan, YN, Rubin, GM

Development 2005
Participants
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of NEUR/MIB1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed