TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase

Stable Identifier
R-DME-209289
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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TAB2 in complex with TAK1 kinase binds to the ubiquitin chains emanating from the Apoptosis 2 Inhibitor (IAP2):Bendless (BEN):UEV1A E3 ligase complex. The formation of an E3 ligase:TAB2:TAK1 complex may cause conformational changes to the catalytic domain of TAK1 thus inducing its kinase activity.
Literature References
PubMed ID Title Journal Year
16081424 The role of ubiquitination in Drosophila innate immunity

Liao, DS, Silverman, N, Chung, Y, Hong, M, Zhou, R, Chen, ZJ, Maniatis, T

J Biol Chem 2005
16894030 The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection

Leulier, F, Lhocine, N, Lemaitre, B, Meier, P

Mol Cell Biol 2006
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